Title |
Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
|
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Published in |
Anais da Academia Brasileira de Ciências, August 2015
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DOI | 10.1590/0001-3765201520140704 |
Pubmed ID | |
Authors |
Ana Caroline Colombo, Marcio L Rodrigues |
Abstract |
Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
France | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 16% |
Student > Bachelor | 7 | 16% |
Student > Master | 5 | 11% |
Student > Ph. D. Student | 4 | 9% |
Professor | 3 | 7% |
Other | 8 | 18% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 16% |
Neuroscience | 6 | 14% |
Agricultural and Biological Sciences | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Nursing and Health Professions | 3 | 7% |
Other | 7 | 16% |
Unknown | 12 | 27% |