Title |
Efficiency of genomic selection using Bayesian multi-marker models for traits selected to reflect a wide range of heritabilities and frequencies of detected quantitative traits loci in mice
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Published in |
BMC Genomic Data, May 2012
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DOI | 10.1186/1471-2156-13-42 |
Pubmed ID | |
Authors |
Dagmar NRG Kapell, Daniel Sorensen, Guosheng Su, Luc LG Janss, Cheryl J Ashworth, Rainer Roehe |
Abstract |
Genomic selection uses dense single nucleotide polymorphisms (SNP) markers to predict breeding values, as compared to conventional evaluations which estimate polygenic effects based on phenotypic records and pedigree information. The objective of this study was to compare polygenic, genomic and combined polygenic-genomic models, including mixture models (labelled according to the percentage of genotyped SNP markers considered to have a substantial effect, ranging from 2.5% to 100%). The data consisted of phenotypes and SNP genotypes (10,946 SNPs) of 2,188 mice. Various growth, behavioural and physiological traits were selected for the analysis to reflect a wide range of heritabilities (0.10 to 0.74) and numbers of detected quantitative traits loci (QTL) (1 to 20) affecting those traits. The analysis included estimation of variance components and cross-validation within and between families. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 7% |
United Kingdom | 2 | 5% |
Mexico | 1 | 2% |
Indonesia | 1 | 2% |
Unknown | 37 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 30% |
Student > Ph. D. Student | 8 | 18% |
Student > Doctoral Student | 4 | 9% |
Student > Master | 4 | 9% |
Professor > Associate Professor | 3 | 7% |
Other | 7 | 16% |
Unknown | 5 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 33 | 75% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Psychology | 1 | 2% |
Unknown | 7 | 16% |