MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

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@RensdeGroot3 https://t.co/LEySrVJulu

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode o… https://t.co/TcFwdgBko5

@BLLPHD @ISCTglobal @LaertisIkonomou @medicine_maker Thanks for sharing 👍 Quote: "Existing protocols for establishing safety and efficacy must be followed, even in exceptional circumstances, such as the COVID-19 pandemic." 👍 Totally agree, please also see

RT @guido_moll: @StemCellsTM Excellent article by Cox and coworkers that also inspired 👉 MSC Therapies for COVID-19: Importance of Patient…

@StemCellsTM Excellent article by Cox and coworkers that also inspired 👉 MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy https://t.co/LEySrVJulu

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @Immunol_papers: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. https://t.co/PneitqtZMB

@Erik_Klok_MD @TromboseLeiden @ThrombosisRese1 @bhwords This extreme #prothrombotic state & propensity for #clotting in #Covid19 patients should be anticipated for any new therapeutic intervention, e.g. for infusing #procoagulant #MSC therapeutics. @th

@harvardmed This extreme #prothrombotic state & propensity for #clotting in #Covid19 patients should be anticipated for any new therapeutic intervention, e.g. for infusing #procoagulant #MSC therapeutics. @thrombosis @StemCellTracker @CGT_Insights http

RT @guido_moll: @pknoepfler Dear @pknoepfler the #clotting you see in this picture done with weakly #CD142 #TissueFactor expressing #MSCs i…

@pknoepfler Dear @pknoepfler the #clotting you see in this picture done with weakly #CD142 #TissueFactor expressing #MSCs in #blood from #healthy donors is nothing compared to what you will get by infusing high doses of CD142+ MSCs in hypercoaguable #Covid

@StemCellTracker Thanks for this excellent summary!!! Here some additional important safety considerations considering MSC therapies for Covid19 👏 https://t.co/LEySrVJulu

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

@Stem_Cell_Dir Any treatment of Covid19 patients should anticipate the extremely hypercoaguable state of these patients, particularly intravenous applications of procoagulant tissue factor expressing MSC therapeutics. https://t.co/LEySrVJulu

@pknoepfler While freeze-thawing and IBMIR are of importance for intravenous use of MSC therapeutics any treatment of Covid19 patients should anticipate the extremely hypercoaguable state of these patients to avoid increases in thrombosis @MesenchymalCell

@AlexSpyropoul Any treatment of Covid19 patients should anticipate this extremely hypercoaguable state https://t.co/LEySrVJulu

@doyley1_ @bhwords @karenbr001 @ThrombosisRese1 Yes, any treatment of Covid19 patients should anticipate this extremely hypercoaguable state https://t.co/LEySrVJulu

RT @alsayeghkn: Review paper تلخص العقبات في استخدام الخلايا الجذعية MSCs لعلاج اضطرابات التنفس لمرضى #كوفيد١٩ https://t.co/1z2dD3NdZr #ا…

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

RT @alsayeghkn: Review paper تلخص العقبات في استخدام الخلايا الجذعية MSCs لعلاج اضطرابات التنفس لمرضى #كوفيد١٩ https://t.co/1z2dD3NdZr #ا…

RT @guido_moll: @coolbro100000 @HaririRobert This would be really fantastic!!! We have all been waiting for the big MSC breakthrough for ma…

Review paper تلخص العقبات في استخدام الخلايا الجذعية MSCs لعلاج اضطرابات التنفس لمرضى #كوفيد١٩ https://t.co/1z2dD3NdZr #الخلايا_الجذعية https://t.co/5KXc8Cnmhu

@coolbro100000 @HaririRobert This would be really fantastic!!! We have all been waiting for the big MSC breakthrough for many decades!!! Covid19 might be the final show-down the make or break. Hopefully no drama, everything is set for make and lets make su

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

RT @HaririRobert: Very valid point, but please realize every cell therapy in trials in #COVID19 went through exhaustive review of existing…

Very valid point, but please realize every cell therapy in trials in #COVID19 went through exhaustive review of existing safety experience and CMC by @US_FDA specifically sensitive to this toxicity. Our trial design even slowly exposes pts monitoring coags

RT @guido_moll: @ASH_hematology Maybe one that will be added in the future: Therapeutic Mesenchymal Stromal Cell (MSC)-induced thrombosis??…

@ASH_hematology Maybe one that will be added in the future: Therapeutic Mesenchymal Stromal Cell (MSC)-induced thrombosis??? Are highly procoagulant tissue factor (TF/CD142)-expressing MSC products really safe to infuse in Covid19??? @EuropeanTHA @ESHaemat

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

RT @guido_moll: @jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these n…

RT @scienzer: #MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Deliver…

@jan_nolta ...while there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately @ISCTgl

RT @scienzer: #MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Deliver…

@EricTopol @JAMANetworkOpen Wow!!! This needs to be monitored carefully!!! Especially when infusing tissue factor (TF/CD142)-expressing Mesenchymal Stromal Cell (MSC) therapeutics for treating Covid-19: https://t.co/LEySrVJulu

RT @NDrzeniek: our recent paper @FrontImmunol emphasizes critical aspects to consider in #stemcell treatment for #COVIDー19 #StayHome

RT @NDrzeniek: our recent paper @FrontImmunol emphasizes critical aspects to consider in #stemcell treatment for #COVIDー19 #StayHome

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @guido_moll: @celltrialsdata Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Proco…

RT @NDrzeniek: our recent paper @FrontImmunol emphasizes critical aspects to consider in #stemcell treatment for #COVIDー19 #StayHome https:…

@LeighGTurner @CellStemCell Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Procoagulant MSC Therapeutics. It is paramount to only use well-characterized, safe MSCs even in the most urgent and experimen

@silviacamporesi @KimmelmanJ @GHSMatKCL @sciencemag Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Procoagulant MSC Therapeutics. It is paramount to only use well-characterized, safe MSCs even in the m

@celltrialsdata Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Procoagulant MSC Therapeutics. It is paramount to only use well-characterized, safe MSCs even in the most urgent and experimental treatmen

@UCDavisStemCell Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Procoagulant MSC Therapeutics. It is paramount to only use well-characterized, safe MSCs even in the most urgent and experimental treatme

@celltrialsdata @cells_nnm @pknoepfler @BLLPHD @LeighGTurner @CaulfieldTim @fverter Hypercoaguability in Covid-19 Patients with Poor Prognosis Mandates Great Caution with IV Delivery of Procoagulant MSC Therapeutics. It is paramount to only use well-charac

RT @NDrzeniek: our recent paper @FrontImmunol emphasizes critical aspects to consider in #stemcell treatment for #COVIDー19 #StayHome https:…

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @MesenchymalCell: A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

A review on #MSC therapies for #COVID-19 from @ChariteBerlin. https://t.co/f3uDfJTOSX https://t.co/htzgbPNwy2

RT @PierFornasari: Thanks Guido for this important update. MSC could be useful to reduce cytokine storm, but hypercoagulability due to neut…

#MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment #safety and #Efficacy Published in @FrontImmunol, @FrontiersIn Shared via @UCDavisGT. https://t.co/eSeYeABtID #C

@thrombosisday @APNews @AlexSpyropoul https://t.co/LEySrVJulu

RT @guido_moll: @ThrombosisCan @YouTube @SYoungPharmD @tsengeric https://t.co/LEySrVJulu

RT @guido_moll: @Medscape https://t.co/LEySrVJulu

RT @guido_moll: @Medscape https://t.co/LEySrVJulu

@AlexSpyropoul https://t.co/LEySrVJulu

@ThrombosisCan @YouTube @SYoungPharmD @tsengeric https://t.co/LEySrVJulu

@ThrombosisUK https://t.co/LEySrVJulu

@Medscape https://t.co/LEySrVJulu

@isth @JTHjournal @AlexSpyropoul @bhwords @JerroldLevy @connors_md @MarcelLevi https://t.co/LEySrVJulu

@DonnaLeinwand @AlexSpyropoul @bhwords @ASH_hematology @isth @womenandclots @HematologyTweet @EHA_Hematology @arianaeunjung @icthicmagazine @JerroldLevy https://t.co/LEySrVJulu

@beaverspharmd @accpcardprn Or a tripple whammy? https://t.co/LEySrVJulu

RT @guido_moll: @JerroldLevy @JTHjournal @AlexSpyropoul @connors_md @bhwords @MarcelLevi https://t.co/LEySrVJulu

@JerroldLevy @JTHjournal @AlexSpyropoul @connors_md @bhwords @MarcelLevi https://t.co/LEySrVJulu

@AlexSpyropoul https://t.co/LEySrVJulu

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

@cells_nnm @sbubnic @pknoepfler @BLLPHD @LeighGTurner @CaulfieldTim @celltrialsdata @fverter Dear Alexey, please check out this, some critical thoughts on the topic: https://t.co/LEySrVJulu

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy https://t.co/qwVIPVsnht

@MarionBrunck @blacksciblog @PLOSONE @FrontMedicine @FrontImmunol @BloodJournal @eLife @TrendsinBiotech Here the links to our prior research topic and current perspective where you can get a feeling for the content: https://t.co/LEySrVJulu https://t.co/B6y

Within one week our perspective article about #MSC for #COVID__19 received more attention than 90% of all research ever tracked by Altmetric. It is ranked #1 of all articles published in @FrontImmunol at a similar time. Don't miss out on this hot topic:

RT @PPimentelCoelho: "...not yet clear whether IV infusion is a safe and effective route of MSC delivery in COVID-19, since MSC-based produ…

RT @RESTOREhorizon: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

RT @RESTOREhorizon: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

RT @PPimentelCoelho: "...not yet clear whether IV infusion is a safe and effective route of MSC delivery in COVID-19, since MSC-based produ…

RT @RESTOREhorizon: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

"...not yet clear whether IV infusion is a safe and effective route of MSC delivery in COVID-19, since MSC-based products express variable levels of highly procoagulant tissue factor (TF/CD142), compromising the cells' hemocompatibility and safety profile"

RT @RESTOREhorizon: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @PierFornasari: Thanks Guido for this important update. MSC could be useful to reduce cytokine storm, but hypercoagulability due to neut…

Thanks Guido for this important update. MSC could be useful to reduce cytokine storm, but hypercoagulability due to neutrophils fire and proteolytic storm https://t.co/cDxhhIIZ4O can be better treated with human plasma as in TTP.

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

RT @guido_moll: MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality an…

MSC Therapies for #COVID19: Safety First!!! Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy @MesenchymalCell @CGT_Insights @TheEBMT @EuropeanTHA @TH_Journal @EHA_Hematology

RT @RESTOREhorizon: MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of De…

our recent paper @FrontImmunol emphasizes critical aspects to consider in #stemcell treatment for #COVIDー19 #StayHome