https://t.co/7OZaqxjw1a "oxidized low-density lipoprotein (oxLDL) and cholesterol crystal-induced macrophage activation and non-steroidal anti-inflammatory drugs- (NSAIDs) induced small intestinal injury."
https://t.co/7OZaqxjw1a "However, its anti-inflammatory role due to inhibition of the NLRP3 inflammasome activation, has also been shown in other conditions such as acute coronary syndrome (ACS),"
https://t.co/7OZaqxjw1a "Subsequently, this led to blocking of the pro-inflammatory IL-1β and IL-18 cytokine production." "Colchicine is frequently used for auto-inflammatory conditions such as gouty arthritis and familial mediterranean fever (FMF)."
https://t.co/7OZaqxjw1a "inducing loss of adhesion molecule L-selectins and preventing adhesion and recruitment of neutrophil, has also been shown to inhibit activation of the NLRP3 inflammasome."
https://t.co/7OZaqxjw1a "More importantly, an alkaloid drug Colchicine which is known for its effects such as tubulin disruption, alteration of E-selectin distribution on endothelial surfaces,"
https://t.co/7OZaqxjw1a "Based on these effects, Tranilast showed significant beneficial effects in animals models of NLRP3 inflammasome-related diseases of humans."
https://t.co/7OZaqxjw1a "Similarly, Tranilast, a drug used for the treatment of allergic conditions such as bronchial asthma, was shown to inhibit the NFkB pathway, several cytokines as well as the NLRP3 oligomerization, thereby preventing the inflammasom
https://t.co/7OZaqxjw1a "Interestingly, Glyburide-mediated inhibition of K+ efflux was shown to inhibit NLRP3 and secretion of IL-1β in cells infected with RNA viruses, i.e., vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV)."
https://t.co/7OZaqxjw1a "Primarily acting by blocking the ATP-sensitive K+ channels (KATP) in β-cells of the pancreas, Glyburide was shown to act upstream and prevent NLRP3 inflammasome activation."
https://t.co/7OZaqxjw1a "Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."
https://t.co/7OZaqxjw1a "Interestingly, parthenolide and Bay 11-7082, inhibiting the NLRP3 inflammasome and inflammatory NFkB pathways, were shown to reduce lung inflammation and improve survival in SARS-CoV-infected animals."
https://t.co/7OZaqxjw1a "and related vinyl sulfone compounds have been shown to exert their effects via inhibition of the NLRP3 inflammasome."
https://t.co/7OZaqxjw1a "Known for their anti-inflammatory properties, natural products such as Oridonin (found in Rabdosia rubescens plant) and Parthenolide (sesquiterpene lactone found in feverfew plant) as well as synthetic compound Bay 11-7082"
Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of #COVID19 #LongCovid #MECFS https://t.co/7OZaqxjw1a
RT @Woodynist: Another rationale for vitamin D (thank you, @fredeyragues). 1/2 Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A…
Another rationale for vitamin D (thank you, @fredeyragues). 1/2 Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19 https://t.co/hqDd7sRiXa
RT @fxfader: Adding to my fxtimelinevx. A different pathway for NLRP3 activation inflammasome formation. There are many cases of 💉 induce…
Adding to my fxtimelinevx. A different pathway for NLRP3 activation inflammasome formation. There are many cases of 💉 induced non life-threatening myocarditis successfully treated with *colchicine.* It blocks this pathway. Next card. https://t.co/UEYex
@EricBillyFR @xazalbert @biomoon_ @Citizen4Sci @Cote_Science Et oui en particulier l inflammasome nlrp3.https://t.co/3cu98drwkh
RT @fredeyragues: @richardursomd @treatingcovid Why it works 1.3 https://t.co/3cu98drwkh
On a depuis longtemps observé que le covid 19 provoquait une réaction immunitaire et induisait une forte activation de l inflammasome nlrp3 https://t.co/3cu98drwkh
@NicolasVdrines1 2/n
On peut donc cibler un traitement qui régule cette activation https://t.co/3cu98drwkh
@__ice9
@france_soir Voilà pourquoi ça marche 1 sur 6 https://t.co/3cu98drwkh
@drbeen_medical
RT @fredeyragues: @drbeen_medical
@drbeen_medical
@gkierzek @raoult_didier @EChabriere
@CorinneReverbel
As this article suggests, agents esp 'Parthenolide' (in feverfew extract) inhibiting NLRP3/NF-kB and other NLRP3 inhibitors (mentioned) can be considered in trials for potential effectiveness against #COVID19 @AAPSonline @DRA_Pakistan @jakramaimc https://t
@sanchak74 for your analyse
@Laissonslespre1
@biobiobiobior
@Stalec_
@medicalfollower
@__ice9 @BabyBoomerWritr @VirusesImmunity There is also this article proposing similar pathway https://t.co/FWpW9goVMe by @DrAdnan_Shah
@xazalbert @france_soir
RT @fredeyragues: @richardursomd @treatingcovid Why it works 1.3 https://t.co/3cu98drwkh
@idrissaberkane
RT @fredeyragues: @richardursomd @treatingcovid Why it works 1.3 https://t.co/3cu98drwkh
RT @fredeyragues: @medicalfollower @moon_bio https://t.co/3cu98drwkh POURQUOI HCL AZI marche 1.3
RT @JeanYvesTarrade: Et encore une pour @BernardSudan https://t.co/7qxj93Jdxc
@BernardSudan pour votre expertise
@medicalfollower @moon_bio https://t.co/3cu98drwkh POURQUOI HCL AZI marche 1.3
Et encore une pour @BernardSudan https://t.co/7qxj93Jdxc
@zev_dr
@Covid19Crusher
RT @fredeyragues: @IHU_Marseille @raoult_didier @EChabriere
@IHU_Marseille @raoult_didier @EChabriere
@JeanYvesTarrade @libe HCL marche car 1.3 https://t.co/jRFNlGjkW6
RT @fredeyragues: @richardursomd @treatingcovid Why it works 1.3 https://t.co/3cu98drwkh
@richardursomd @treatingcovid Why it works 1.3 https://t.co/3cu98drwkh
@biobiobiobior Voilà pourquoi ça marche https://t.co/3cu98drwkh
RT @DrAdnan_Shah: My article "Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19…
RT @DrAdnan_Shah: My article "Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19…
RT @DrAdnan_Shah: My article "Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19…
RT @gstanchev: Another article by @DrAdnan_Shah about NLRP3 activation in SARS-CoV-2 and potential of treatment of COVID19 by suppressing i…
Another article by @DrAdnan_Shah about NLRP3 activation in SARS-CoV-2 and potential of treatment of COVID19 by suppressing its activation https://t.co/FWpW9goVMe
RT @DrAdnan_Shah: My article "Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19…
@JaneSmitham
My article "Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19". https://t.co/nO714UOCNB