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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

Overview of attention for article published in Cell Division, May 2016
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1 tweeter

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Title
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
Published in
Cell Division, May 2016
DOI 10.1186/s13008-016-0020-7
Pubmed ID
Authors

Weijia Cai, Haifeng Yang

Abstract

Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases. First, the composition, structure and the regulation of Cullin-2 based E3 ubiquitin ligases were introduced. Then the targets, the biological functions of complexes that use VHL, Lrr-1, Fem1b, Prame, Zyg-11, BAF250, Rack1 as substrate targeting subunits were described, and their involvement in diseases was discussed. A small molecule inhibitor of Cullins as a potential anti-cancer drug was introduced. Furthermore, proteins with VHL box that might bind to Cullin-2 were described. Finally, how different viral proteins form E3 ubiquitin ligase complexes with Cullin-2 to counter host viral defense were explained. Cullin-2 based E3 ubiquitin ligases, using many different substrate recognition receptors, recognize a number of substrates and regulate their protein stability. These complexes play critical roles in biological processes and diseases such as cancer, germline differentiation and viral defense. Through the better understanding of their biology, we can devise and develop new therapeutic strategies to treat cancers, inherited diseases and viral infections.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 37%
Researcher 10 15%
Student > Bachelor 7 11%
Professor > Associate Professor 5 8%
Student > Master 5 8%
Other 8 12%
Unknown 6 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 32%
Agricultural and Biological Sciences 14 22%
Chemistry 8 12%
Immunology and Microbiology 6 9%
Medicine and Dentistry 5 8%
Other 4 6%
Unknown 7 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2016.
All research outputs
#6,766,441
of 7,811,999 outputs
Outputs from Cell Division
#48
of 56 outputs
Outputs of similar age
#224,049
of 268,966 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
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So far Altmetric has tracked 56 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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