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Mendeley readers
Attention Score in Context
| Title |
Progranulin regulates neuronal outgrowth independent of Sortilin
|
|---|---|
| Published in |
Molecular Neurodegeneration, July 2012
|
| DOI | 10.1186/1750-1326-7-33 |
| Pubmed ID | |
| Authors |
Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch, Caroline Stetler, Karen Jansen-West, Jada Lewis, Christopher D Link, Rosa Rademakers, Anders Nykjær, Leonard Petrucelli |
| Abstract |
Progranulin (PGRN), a widely secreted growth factor, is involved in multiple biological functions, and mutations located within the PGRN gene (GRN) are a major cause of frontotemporal lobar degeneration with TDP-43-positive inclusions (FLTD-TDP). In light of recent reports suggesting PGRN functions as a protective neurotrophic factor and that sortilin (SORT1) is a neuronal receptor for PGRN, we used a Sort1-deficient (Sort1-/-) murine primary hippocampal neuron model to investigate whether PGRN's neurotrophic effects are dependent on SORT1. We sought to elucidate this relationship to determine what role SORT1, as a regulator of PGRN levels, plays in modulating PGRN's neurotrophic effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Unknown | 124 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 23% |
| Researcher | 28 | 22% |
| Student > Master | 15 | 12% |
| Student > Bachelor | 10 | 8% |
| Student > Doctoral Student | 6 | 5% |
| Other | 18 | 14% |
| Unknown | 20 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 27% |
| Neuroscience | 28 | 22% |
| Biochemistry, Genetics and Molecular Biology | 20 | 16% |
| Medicine and Dentistry | 11 | 9% |
| Chemistry | 5 | 4% |
| Other | 6 | 5% |
| Unknown | 22 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2024.
All research outputs
#5,415,901
of 25,654,806 outputs
Outputs from Molecular Neurodegeneration
#653
of 988 outputs
Outputs of similar age
#35,596
of 178,548 outputs
Outputs of similar age from Molecular Neurodegeneration
#6
of 17 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 988 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,548 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.