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Cerebral Cavernous Malformations (CCM)

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Cover of 'Cerebral Cavernous Malformations (CCM)'

Table of Contents

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    Book Overview
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    Chapter 1 From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 2 Incidence, Prevalence, and Clinical Presentation of Cerebral Cavernous Malformations
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    Chapter 3 Natural History, Clinical, and Surgical Management of Cavernous Malformations
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    Chapter 4 Molecular Genetic Screening of CCM Patients: An Overview
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    Chapter 5 Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 6 Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity
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    Chapter 7 Clinical Imaging of Cerebral Cavernous Malformations: Computed Tomography and Magnetic Resonance Imaging
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    Chapter 8 Neuroradiology: Differential Diagnosis, Follow-Up, and Reporting
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    Chapter 9 Surgical Management of Brain Cavernous Malformations
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    Chapter 10 Generation of CCM Phenotype by a Human Microvascular Endothelial Model
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    Chapter 11 Isolation and Purification of Mouse Brain Endothelial Cells to Study Cerebral Cavernous Malformation Disease
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    Chapter 12 Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease
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    Chapter 13 CRISPR/Cas9-mediated Generation of Human Endothelial Cell Knockout Models of CCM Disease
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    Chapter 14 Dissection of the Role of CCM Genes in Tubulogenesis Using the Drosophila Tracheal System as a Model
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    Chapter 15 Generation and Analysis of CCM Phenotypes in C. elegans
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    Chapter 16 Generation of Transgenic Lines of Zebrafish Expressing Fluorescently Tagged CCM Proteins to Study Their Function and Subcellular Localization Within the Vasculature
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    Chapter 17 Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model
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    Chapter 18 Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy
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    Chapter 19 Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain
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    Chapter 20 Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System
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    Chapter 21 Crystallographic Studies of the Cerebral Cavernous Malformations Proteins
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    Chapter 22 Microscopy Techniques to Investigate CCM Pathogenesis
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    Chapter 23 Preparation and Analysis of Protein Extracts to Investigate CCM Pathogenesis
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    Chapter 24 Systems Wide Analysis of CCM Signaling Complex Alterations in CCM-Deficient Models Using Omics Approaches
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    Chapter 25 Study of Molecular Interactions of CCM Proteins by Using a GAL4-Based Yeast Two-Hybrid Screening
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    Chapter 26 Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model
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    Chapter 27 Bidimentional In Vitro Angiogenic Assays to Study CCM Pathogenesis: Endothelial Cell Proliferation and Migration
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    Chapter 28 Measurement of Endothelial Barrier Function in Mouse Models of Cerebral Cavernous Malformations Using Intravital Microscopy
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    Chapter 29 Immunofluorescence of Cell–Cell and Cell–Extracellular Matrix Adhesive Defects in In Vitro Endothelial CCM Model: Juxtacrine Role of Mutant Extracellular Matrix on Wild-Type Endothelial Cells
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    Chapter 30 Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence
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    Chapter 31 Notch Signaling in Familial Cerebral Cavernous Malformations and Immunohistochemical Detection of Cleaved Notch1 Intracellular Domain
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    Chapter 32 Measuring the Kinase Activity of GCKIII Proteins In Vitro
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    Chapter 33 Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 34 Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease
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    Chapter 35 Library Preparation for Small RNA Transcriptome Sequencing in Patients Affected by Cerebral Cavernous Malformations
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    Chapter 36 Affinity Purification and Preparation of Peptides for Mass Spectrometry from C. elegans
Attention for Chapter 15: Generation and Analysis of CCM Phenotypes in C. elegans
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Chapter title
Generation and Analysis of CCM Phenotypes in C. elegans
Chapter number 15
Book title
Cerebral Cavernous Malformations (CCM)
Published in
Methods in molecular biology, January 2020
DOI 10.1007/978-1-0716-0640-7_15
Pubmed ID
Book ISBNs
978-1-07-160639-1, 978-1-07-160640-7
Authors

Evelyn Popiel, William Brent Derry, Popiel, Evelyn, Derry, William Brent

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The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

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This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2020.
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