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Cerebral Cavernous Malformations (CCM)

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Cover of 'Cerebral Cavernous Malformations (CCM)'

Table of Contents

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    Book Overview
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    Chapter 1 From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 2 Incidence, Prevalence, and Clinical Presentation of Cerebral Cavernous Malformations
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    Chapter 3 Natural History, Clinical, and Surgical Management of Cavernous Malformations
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    Chapter 4 Molecular Genetic Screening of CCM Patients: An Overview
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    Chapter 5 Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 6 Genome-wide Genotyping of Cerebral Cavernous Malformation Type 1 Individuals to Identify Genetic Modifiers of Disease Severity
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    Chapter 7 Clinical Imaging of Cerebral Cavernous Malformations: Computed Tomography and Magnetic Resonance Imaging
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    Chapter 8 Neuroradiology: Differential Diagnosis, Follow-Up, and Reporting
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    Chapter 9 Surgical Management of Brain Cavernous Malformations
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    Chapter 10 Generation of CCM Phenotype by a Human Microvascular Endothelial Model
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    Chapter 11 Isolation and Purification of Mouse Brain Endothelial Cells to Study Cerebral Cavernous Malformation Disease
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    Chapter 12 Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease
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    Chapter 13 CRISPR/Cas9-mediated Generation of Human Endothelial Cell Knockout Models of CCM Disease
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    Chapter 14 Dissection of the Role of CCM Genes in Tubulogenesis Using the Drosophila Tracheal System as a Model
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    Chapter 15 Generation and Analysis of CCM Phenotypes in C. elegans
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    Chapter 16 Generation of Transgenic Lines of Zebrafish Expressing Fluorescently Tagged CCM Proteins to Study Their Function and Subcellular Localization Within the Vasculature
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    Chapter 17 Vertebrate Models to Investigate CCM Pathogenesis: The Zebrafish and Mouse Model
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    Chapter 18 Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy
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    Chapter 19 Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain
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    Chapter 20 Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System
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    Chapter 21 Crystallographic Studies of the Cerebral Cavernous Malformations Proteins
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    Chapter 22 Microscopy Techniques to Investigate CCM Pathogenesis
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    Chapter 23 Preparation and Analysis of Protein Extracts to Investigate CCM Pathogenesis
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    Chapter 24 Systems Wide Analysis of CCM Signaling Complex Alterations in CCM-Deficient Models Using Omics Approaches
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    Chapter 25 Study of Molecular Interactions of CCM Proteins by Using a GAL4-Based Yeast Two-Hybrid Screening
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    Chapter 26 Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model
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    Chapter 27 Bidimentional In Vitro Angiogenic Assays to Study CCM Pathogenesis: Endothelial Cell Proliferation and Migration
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    Chapter 28 Measurement of Endothelial Barrier Function in Mouse Models of Cerebral Cavernous Malformations Using Intravital Microscopy
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    Chapter 29 Immunofluorescence of Cell–Cell and Cell–Extracellular Matrix Adhesive Defects in In Vitro Endothelial CCM Model: Juxtacrine Role of Mutant Extracellular Matrix on Wild-Type Endothelial Cells
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    Chapter 30 Detection of p62/SQSTM1 Aggregates in Cellular Models of CCM Disease by Immunofluorescence
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    Chapter 31 Notch Signaling in Familial Cerebral Cavernous Malformations and Immunohistochemical Detection of Cleaved Notch1 Intracellular Domain
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    Chapter 32 Measuring the Kinase Activity of GCKIII Proteins In Vitro
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    Chapter 33 Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease
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    Chapter 34 Fluorescence Analysis of Reactive Oxygen Species (ROS) in Cellular Models of Cerebral Cavernous Malformation Disease
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    Chapter 35 Library Preparation for Small RNA Transcriptome Sequencing in Patients Affected by Cerebral Cavernous Malformations
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    Chapter 36 Affinity Purification and Preparation of Peptides for Mass Spectrometry from C. elegans
Attention for Chapter 15: Generation and Analysis of CCM Phenotypes in C. elegans
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Chapter title
Generation and Analysis of CCM Phenotypes in C. elegans
Chapter number 15
Book title
Cerebral Cavernous Malformations (CCM)
Published in
Methods in molecular biology, January 2020
DOI 10.1007/978-1-0716-0640-7_15
Pubmed ID
Book ISBNs
978-1-07-160639-1, 978-1-07-160640-7

Evelyn Popiel, William Brent Derry, Popiel, Evelyn, Derry, William Brent

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