Title |
Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study
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Published in |
The Journal of Headache and Pain, May 2016
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DOI | 10.1186/s10194-016-0650-9 |
Pubmed ID | |
Authors |
Cherubino Di Lorenzo, Gianluca Coppola, Martina Bracaglia, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Vincenzo Parisi, Francesco Pierelli |
Abstract |
Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine. Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs. After 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks. KD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level. |
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Geographical breakdown
Country | Count | As % |
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United States | 6 | 8% |
Argentina | 4 | 6% |
Canada | 3 | 4% |
Australia | 3 | 4% |
Brazil | 3 | 4% |
Mexico | 2 | 3% |
Italy | 2 | 3% |
Chile | 2 | 3% |
Other | 6 | 8% |
Unknown | 30 | 42% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 7 | 10% |
Scientists | 4 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
United States | 1 | <1% |
Unknown | 100 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 16 | 16% |
Researcher | 12 | 12% |
Student > Master | 10 | 10% |
Student > Doctoral Student | 10 | 10% |
Other | 6 | 6% |
Other | 17 | 17% |
Unknown | 31 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 21% |
Neuroscience | 10 | 10% |
Nursing and Health Professions | 8 | 8% |
Psychology | 5 | 5% |
Agricultural and Biological Sciences | 4 | 4% |
Other | 16 | 16% |
Unknown | 38 | 37% |