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Annihilation of Leishmania by daylight responsive ZnO nanoparticles: a temporal relationship of reactive oxygen species-induced lipid and protein oxidation

Overview of attention for article published in International Journal of Nanomedicine, May 2016
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
7 tweeters

Citations

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22 Dimensions

Readers on

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39 Mendeley
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Title
Annihilation of Leishmania by daylight responsive ZnO nanoparticles: a temporal relationship of reactive oxygen species-induced lipid and protein oxidation
Published in
International Journal of Nanomedicine, May 2016
DOI 10.2147/ijn.s105195
Pubmed ID
Authors

Akhtar Nadhman, Malik Ihsanullah Khan, Samina Nazir, Momin Khan, Gul Shahnaz, Abida Rao, Dilawar Shams, Masoom Yasinzai

Abstract

Lipid and protein oxidation are well-known manifestations of free radical activity and oxidative stress. The current study investigated extermination of Leishmania tropica promastigotes induced by lipid and protein oxidation with reactive oxygen species produced by PEGylated metal-based nanoparticles. The synthesized photodynamic therapy-based doped and nondoped zinc oxide nanoparticles were activated in daylight that produced reactive oxygen species in the immediate environment. Lipid and protein oxidation did not occur in dark. The major lipid peroxidation derivatives comprised of conjugated dienes, lipid hydroperoxides, and malondialdehyde whereas water, ethane, methanol, and ethanol were found as the end products. Proteins were oxidized to carbonyls, hydroperoxides, and thiol degrading products. Interestingly, lipid hydroperoxides were produced by more than twofold of the protein hydroperoxides, indicating higher degradation of lipids compared to proteins. The in vitro evidence represented a significant contribution of the involvement of both lipid and protein oxidation in the annihilated antipromastigote effect of nanoparticles.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 18%
Student > Doctoral Student 5 13%
Student > Master 5 13%
Student > Bachelor 4 10%
Researcher 3 8%
Other 6 15%
Unknown 9 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 18%
Agricultural and Biological Sciences 6 15%
Chemistry 5 13%
Medicine and Dentistry 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 6 15%
Unknown 9 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2016.
All research outputs
#2,521,316
of 9,728,122 outputs
Outputs from International Journal of Nanomedicine
#228
of 2,076 outputs
Outputs of similar age
#86,281
of 277,378 outputs
Outputs of similar age from International Journal of Nanomedicine
#13
of 119 outputs
Altmetric has tracked 9,728,122 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,076 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.