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The impact of patient co-morbidities on the regenerative capacity of cardiac explant-derived stem cells

Overview of attention for article published in Stem Cell Research & Therapy, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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11 tweeters

Citations

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20 Dimensions

Readers on

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52 Mendeley
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Title
The impact of patient co-morbidities on the regenerative capacity of cardiac explant-derived stem cells
Published in
Stem Cell Research & Therapy, May 2016
DOI 10.1186/s13287-016-0321-4
Pubmed ID
Authors

Audrey E. Mayfield, Megan E. Fitzpatrick, Nicholas Latham, Everad L. Tilokee, Melanie Villanueva, Seth Mount, Bu-Khanh Lam, Marc Ruel, Duncan J. Stewart, Darryl R. Davis

Abstract

Although patient-sourced cardiac stem cells repair damaged myocardium, the extent to which medical co-morbidities influence cardiac-derived cell products is uncertain. Therefore, we investigated the influence of atherosclerotic risk factors on the regenerative performance of human cardiac explant-derived cells (EDCs). In this study, the Long Term Stratification for survivors of acute coronary syndromes model was used to quantify the burden of cardiovascular risk factors within a group of patients with established atherosclerosis. EDCs were cultured from human atrial appendages and injected into immunodeficient mice 7 days post-left coronary ligation. Cytokine arrays and enzyme linked immunoassays were used to determine the release of cytokines by EDCs in vitro, and echocardiography was used to determine regenerative capabilities in vivo. EDCs sourced from patients with more cardiovascular risk factors demonstrated a negative correlation with production of pro-healing cytokines (such as stromal cell derived factor 1α) and exosomes which had negative effects on the promotion of angiogenesis and chemotaxis. Reductions in exosomes and pro-healing cytokines with accumulating medical co-morbidities were associated with increases in production of the pro-inflammatory cytokine interleukin-6 (IL-6) by EDCs. Increased patient co-morbidities were also correlated with significant attenuation in improvements of left ventricular ejection fraction. The regenerative performance of the earliest precursor cell population cultured from human explant tissue declines with accumulating medical co-morbidities. This effect is associated with diminished production of pro-cardiogenic cytokines and exosomes while IL-6 is markedly increased. Predictors of cardiac events demonstrated a lower capacity to support angiogenesis and repair injured myocardium in a mouse model of myocardial infarction.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Student > Ph. D. Student 7 13%
Researcher 6 12%
Student > Doctoral Student 6 12%
Other 5 10%
Other 8 15%
Unknown 12 23%
Readers by discipline Count As %
Medicine and Dentistry 17 33%
Biochemistry, Genetics and Molecular Biology 10 19%
Agricultural and Biological Sciences 5 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Nursing and Health Professions 1 2%
Other 4 8%
Unknown 13 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2020.
All research outputs
#2,978,636
of 15,534,842 outputs
Outputs from Stem Cell Research & Therapy
#306
of 1,459 outputs
Outputs of similar age
#63,099
of 268,923 outputs
Outputs of similar age from Stem Cell Research & Therapy
#4
of 11 outputs
Altmetric has tracked 15,534,842 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,459 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,923 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.