RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: It's beautiful to see this one year after my model was publish from theory based on clinical data available up to Apri…
It's beautiful to see this one year after my model was publish from theory based on clinical data available up to April 2020. It's in line with Akiko longitudinal study anniversary soon too. https://t.co/CtnosSZtam
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
@RheumNow I suggested the use of BPPs in my two-hit model of COVID written in April for reasons of reducing the acute lung injury amplification by the inflammatory monocytes and their infiltrate. You can find it here. https://t.co/CtnosSHRLM
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: @ImmunoFever it seems that the body is sensitive to a two-hit injury. I wonder what would happen if you add kidney/liv…
@ImmunoFever it seems that the body is sensitive to a two-hit injury. I wonder what would happen if you add kidney/liver involvement in the graph. The model I put up reading SARS literature would suggest a loop lung-system https://t.co/CtnosSZtam
Elegant paper on the potential mechanisms of severe COVID19. The initial lung injury by the virus (1st hit) is compounded in a few by a ‘2nd hit’, which is the result of inflammation from comorbidity. This leads to a self-propelling cycle of destruct
@ArditiMd @RajeevJayadevan @VirusesImmunity Yes, agreed. And that's what we proposed as a model for covid19 some months ago too. A two hit model that accounts for this and for the immunological misfiring ;) https://t.co/CtnosSZtam
Already contemplated in our model. But brains are supercomputers... No surprise. And we did separate the RAS/KKS branch from the classic inflammatory edema -> system -> lung failure -> MOF because it can happen without them... https://t.co/Ctnos
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19. https://t.co/xB3oaA5Ntl
RT @FrontImmunol: New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains S…
RT @RafaelPolidoro2: Thanks @FrontImmunol for tweeting our model. It's been quite good model and since mid April when I designed it (based…
Thanks @FrontImmunol for tweeting our model. It's been quite good model and since mid April when I designed it (based on conservative SIRS-ALI literature), it's been confirmed dozen times so far. Immature granulocytes still surprise immunologists, but not
RT @FrontImmunol: New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains S…
RT @FrontImmunol: New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains S…
RT @FrontImmunol: New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains S…
RT @FrontImmunol: New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains S…
New Research: Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19: Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some patients,… https://t.co/6
@ChrisBlec And if you want to understand more about what is actually happening in the body, and why this thing is so nasty, there are a few models that try to understand how the virus is working. Here's one of them: https://t.co/X3Z6Xh6iYJ
@EricTopol @NatureMedicine @ScienceMagazine @ImmunityCP well, this is not a novelty. And ARDS (SIRS-ALI) literature had it all written before. Spiced by ACE2 malfunction. Applied to COVID-19 unifying model here: @FrontImmunol https://t.co/CtnosSZtam
@CyrilPedia Sensacional, eu cheguei a falar disso na minha revisão tb, mas o nível de detalhe deste trabalho pra cada sistema é sensacional. Eu tô procurando confirmação da ação direta de toxicidade viral TB, é a parte q não tem em modelos animais de ARDS
@FredLAFernandes @macedo_inv Anticoagulante não é específico pra covid e foi usado em casos com alto D dimeros e trombocitopenia. Como é de praxe. Acho que há certa confusão do público no que é anti COVID e o que ajuda a dirimir o dano sistêmico derivado
@luizacaires3 Você vê, depois que publiquei o modelo de desenvolvimento de covid usando a literatura (e alguns artigos de autópsia saíram como preprint na minha revisão), uma empresa que produz inibidores de KKS me contactou para deliberarmos testes. O dra
RT @RafaelPolidoro2: @bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativ…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: @bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativ…
RT @RafaelPolidoro2: @bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativ…
RT @RafaelPolidoro2: @bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativ…
RT @RafaelPolidoro2: @bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativ…
@bollemdb @dogarrett A apresentação da COVID-19 tem origem em lesão pulmonar, como outros vírus respiratórios com ativação sistêmica e com grandes chances de voltar ao pulmão e causar SRAG e falência respiratória (maior causa de morte) + https://t.co/Ctnos
RT @NathanWSchmidt1: Excited to be a part of this work! https://t.co/iMgH1jImsV
@DaniOliver I'm so sorry to hear all this. Rashes would be hard to explain without RAS-KKS involvement with microthrombosis. Tachycardia maybe due to bradykinin excess. I try to make sense of those using established diseases models here https://t.co/Ctno
@nature You need two hits to get an animal model of lung injury leading to ARDS/systemic inflammation. It's well described in the literature and might help in COVID-19. tip: Lavezzo et al in Nature yesterday shows no dif in viral load with or without sympt
This was the motivation of my framework! Placing SIRS-CALI into the literature perspective is essential to find solutions. @Greguialmeida will be thrilled to read https://t.co/CtnosSZtam
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
@KingOfPathogens @ImmunityCP Congrats on this amazing piece, @KingOfPathogens and Nilam Mangalmurti about this great villain in COVID-19: Cytokine storms. And here I share an overview on how the infections leads to that point https://t.co/CtnosSZtam
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
@ImmunityCP I'd rather say, understanding the cytokine storm related to covid-19 As it is a consequence of Covid19 associated lung injury in a rich cascade of clinical features. https://t.co/CtnosSZtam
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @statfourwork: Congratulations @NathanWSchmidt1 on your newly published @FrontiersIn article: https://t.co/Le2wQvEZ76
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
Excited to be a part of this work!
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @jaggeree: This is an incredible overview. To think that all the work leading to this overview had been performed at pace and scale in t…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @statfourwork: Congratulations @NathanWSchmidt1 on your newly published @FrontiersIn article: https://t.co/Le2wQvEZ76
Very interesting. Curious what kind of response this 2-hit model of COVID19 lung pathology will receive. Seems logical on the surface...
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
Congratulations @NathanWSchmidt1 on your newly published @FrontiersIn article: https://t.co/Le2wQvEZ76
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19 https://t.co/b4As3aj7oD
This is an incredible overview. To think that all the work leading to this overview had been performed at pace and scale in the middle of a pandemic caused by a novel virus which causes a collection of complex syndromes.
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
RT @RafaelPolidoro2: Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic in…
Very excited to share our overview on the pathological development of severe COVID-19 under a conservative systemic inflammation derived from COVID-19 associated lung injury (CALI) two hit model consistent with current data 👇🏾 https://t.co/CtnosSZtam
RT @RafaelPolidoro2: @AlexanderDent6 The abstract of my model is already online. But I think the paper will only come out tomorrow. We try…
@AlexanderDent6 The abstract of my model is already online. But I think the paper will only come out tomorrow. We try to address a little bit one aspect that can explain this... https://t.co/rJEr9j04bE