Title |
Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
|
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Published in |
Skeletal Muscle, July 2012
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DOI | 10.1186/2044-5040-2-15 |
Pubmed ID | |
Authors |
Caterina Bernacchioni, Francesca Cencetti, Sabrina Blescia, Chiara Donati, Paola Bruni |
Abstract |
Insulin-like growth factor-1 (IGF-1) is the most important physiological regulator of skeletal muscle progenitor cells, which are responsible for adult skeletal muscle regeneration. The ability of IGF-1 to affect multiple aspects of skeletal muscle cell biology such as proliferation, differentiation, survival and motility is well recognized, although the molecular mechanisms implicated in its complex biological action are not fully defined. Since sphingosine 1-phosphate (S1P) has recently emerged as a key player in skeletal muscle regeneration, we investigated the possible involvement of the sphingosine kinase (SK)/S1P receptor axis on the biological effects of IGF-1 in murine myoblasts. |
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Mendeley readers
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Student > Bachelor | 7 | 20% |
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Other | 3 | 9% |
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