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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection
|
|---|---|
| Published in |
Radiation Oncology, June 2016
|
| DOI | 10.1186/s13014-016-0653-3 |
| Pubmed ID | |
| Authors |
Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Davide Franceschini, Angelo Tozzi, Giuseppe D’Agostino, Tiziana Comito, Cristina Iftode, Giulia Maggi, Giacomo Reggiori, Lorenzo Bello, Marta Scorsetti |
| Abstract |
Hypo-fractionated stereotactic radiotherapy (HSRT) is emerging as a valid treatment option for patients with single, large brain metastases (BMs). We analyzed a set of our patients treated with HSRT. The aim of this study was to evaluate local control (LC), brain distant progression (BDP), toxicity and overall survival (OS). From July 2011 to May 2015, 102 patients underwent HSRT consisting of 27Gy/3fractions for lesions 2.1-3 cm and 32Gy/4 fractions for lesions 3.1-5 cm. Local progression was defined as increase of the enhancing abnormality on MRI, and distant progression as new brain metastases outside the irradiated volume. Toxicity in terms of radio-necrosis was assessed using contrast enhanced T1MRI, T2 weighted-MRI and perfusion- MRI. The median maximum diameter of BM was 2.9 cm (range 2.1-5 cm), the median gross target volume (GTV) was 16.3 cm(3) and the median planning target volume (PTV) was 33.7 cm(3) The median,1,2-year local control rate was 30 months, 96, 96 %; the median, 1-2-year rate of BDP was 24 months, 12, 24 %; the median,1,2-year OS was 14 months, 69, 33 %. KPS and controlled extracranial disease were associated with significant survival benefit (p <0.01). Brain radio-necrosis occurred in six patients (5.8 %). In patients with single, large BMs unsuitable for surgical resection, HSRT is a safe and feasible treatment, with good brain local control and limited toxicity. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 19% |
| Other | 11 | 15% |
| Student > Postgraduate | 10 | 14% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 4 | 5% |
| Other | 8 | 11% |
| Unknown | 19 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 52% |
| Physics and Astronomy | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Social Sciences | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 24 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2022.
All research outputs
#5,975,864
of 23,860,205 outputs
Outputs from Radiation Oncology
#234
of 2,127 outputs
Outputs of similar age
#93,490
of 342,622 outputs
Outputs of similar age from Radiation Oncology
#4
of 37 outputs
Altmetric has tracked 23,860,205 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,127 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,622 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.