Intraventricular antibiotics for bacterial meningitis in neonates
Cochrane database of systematic reviews, July 2012
Sachin S Shah, Arne Ohlsson, Vibhuti S Shah
Neonatal meningitis may be caused by bacteria, especially gram-negative bacteria, which are difficult to eradicate from the cerebrospinal fluid (CSF) using safe doses of antibiotics. In theory, intraventricular administration of antibiotics would produce higher antibiotic concentrations in the CSF than intravenous administration alone, and eliminate the bacteria more quickly. However, ventricular taps may cause harm.
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