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Methylphenidate for Treating ADHD: A Naturalistic Clinical Study of Methylphenidate Blood Concentrations in Children and Adults With Optimized Dosage

Overview of attention for article published in European Journal of Drug Metabolism and Pharmacokinetics, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 132)
  • Good Attention Score compared to outputs of the same age (71st percentile)

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5 tweeters

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8 Mendeley
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Title
Methylphenidate for Treating ADHD: A Naturalistic Clinical Study of Methylphenidate Blood Concentrations in Children and Adults With Optimized Dosage
Published in
European Journal of Drug Metabolism and Pharmacokinetics, May 2016
DOI 10.1007/s13318-016-0346-1
Pubmed ID
Authors

Chermá, Maria D, Josefsson, Martin, Rydberg, Irene, Woxler, Per, Trygg, Tomas, Hollertz, Olle, Gustafsson, Per A, Maria D. Chermá, Martin Josefsson, Irene Rydberg, Per Woxler, Tomas Trygg, Olle Hollertz, Per A. Gustafsson

Abstract

Methylphenidate (MPH), along with behavioral and psychosocial interventions, is the first-line medication to treat attention-deficit hyperactivity disorder (ADHD) in Sweden. The dose of MPH for good symptom control differs between patients. However, studies of MPH concentration measurement in ADHD treatment are limited. To describe blood and oral fluid (OF) concentrations of MPH after administration of medication in patients with well-adjusted MPH treatment for ADHD, and to identify the most suitable matrix for accurate MPH concentration during treatment. Patients were recruited from Child and Adolescent Psychiatry (CAP), General Psychiatry (GP), and the Department of Dependency (DD). Blood and OF samples were collected in the morning before MPH administration as well as 1 and 6 h after administration of the prescribed morning dose of MPH. Fifty-nine patients aged between 9 and 69 years, 76 % males. The daily dose of MPH varied from 18 to 180 mg, but the median daily dose per body weight was similar, approximately 1.0 mg/kg body weight. The median MPH concentration in blood 1 and 6 h after the morning dose was 5.4 and 9.3 ng/mL, respectively. Highly variable OF-to-blood ratios for MPH were found at all time points for all three groups. Weight is a reliable clinical parameter for optimal dose titration. Otherwise, MPH blood concentration might be used for individual dose optimization and for monitoring of the prescribed dose. Relying only on the outcome in OF cannot be recommended for evaluation of accurate MPH concentrations for treatment monitoring.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 13%
Unknown 7 88%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 25%
Researcher 2 25%
Student > Master 1 13%
Student > Ph. D. Student 1 13%
Librarian 1 13%
Other 1 13%
Readers by discipline Count As %
Psychology 4 50%
Pharmacology, Toxicology and Pharmaceutical Science 2 25%
Unspecified 1 13%
Chemistry 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2017.
All research outputs
#1,902,221
of 8,360,145 outputs
Outputs from European Journal of Drug Metabolism and Pharmacokinetics
#12
of 132 outputs
Outputs of similar age
#76,938
of 273,360 outputs
Outputs of similar age from European Journal of Drug Metabolism and Pharmacokinetics
#2
of 4 outputs
Altmetric has tracked 8,360,145 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 132 research outputs from this source. They receive a mean Attention Score of 2.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.