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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
|
|---|---|
| Published in |
Immunity & Ageing, June 2016
|
| DOI | 10.1186/s12979-016-0076-x |
| Pubmed ID | |
| Authors |
Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek, Malgorzata Mossakowska |
| Abstract |
In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly. IL-6 and CRP levels systematically increased in an age-dependent manner in the entire study group (IL-6: n = 3496 individuals, p < 0.001 and CRP: n = 3632, p = 0.003), and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease, myocardial infarction, stroke, type 2 diabetes, or cancer, and had a Mini Mental State Examination (MMSE) score ≥24 and a Katz Activities of Daily Living (ADL) score ≥5 (IL-6: n = 1258, p < 0.001 and CRP: n = 1312, p < 0.001). In the subgroup of individuals suffering from aging-related diseases/disability, only IL-6 increased with age (IL-6: n = 2238, p < 0.001 and CRP: n = 2320, p = 0.249). IL-6 and CRP levels were lower in successfully aging individuals than in the remaining study participants (both p < 0.001). Higher IL-6 and CRP levels were associated with poorer physical performance (lower ADL score) and poorer cognitive performance (lower MMSE score) (both p < 0.001). This association remained significant after adjusting for age, gender, BMI, lipids, estimated glomerular filtration rate, and smoking status. Longer survival was associated with lower concentrations of IL-6 and CRP not only in individuals with aging-related diseases/disability (HR = 1.063 per each pg/mL, 95 % CI: 1.052-1.074, p < 0.001 and HR = 1.020 per each mg/L, 95 % CI: 1.015-1.025, p < 0.001, respectively) but also in the successfully aging subgroup (HR = 1.163 per each pg/mL, 95 % CI: 1.128-1.199, p < 0.001 and HR = 1.074 per each mg/L, 95 % CI: 1.047-1.100, p < 0.001, respectively). These associations remained significant after adjusting for age, gender, BMI, lipids and smoking status. The Kaplan-Meier survival curves showed similar results (all p < 0.001). Both IL-6 and CRP levels were good predictors of physical and cognitive performance and the risk of mortality in both the entire elderly population and in successfully aging individuals. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 31% |
| United Kingdom | 3 | 23% |
| Portugal | 1 | 8% |
| Norway | 1 | 8% |
| Chile | 1 | 8% |
| Unknown | 3 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 54% |
| Practitioners (doctors, other healthcare professionals) | 3 | 23% |
| Science communicators (journalists, bloggers, editors) | 2 | 15% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 359 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Netherlands | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 356 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 13% |
| Student > Bachelor | 44 | 12% |
| Student > Master | 43 | 12% |
| Researcher | 34 | 9% |
| Student > Doctoral Student | 21 | 6% |
| Other | 61 | 17% |
| Unknown | 108 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 67 | 19% |
| Biochemistry, Genetics and Molecular Biology | 46 | 13% |
| Agricultural and Biological Sciences | 24 | 7% |
| Nursing and Health Professions | 19 | 5% |
| Immunology and Microbiology | 19 | 5% |
| Other | 57 | 16% |
| Unknown | 127 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2022.
All research outputs
#1,198,020
of 24,250,928 outputs
Outputs from Immunity & Ageing
#35
of 406 outputs
Outputs of similar age
#22,758
of 345,053 outputs
Outputs of similar age from Immunity & Ageing
#2
of 8 outputs
Altmetric has tracked 24,250,928 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 406 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.