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Battle over CCL2 for control of the metastatic niche: neutrophils versus monocytes

Overview of attention for article published in Breast Cancer Research, July 2012
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Title
Battle over CCL2 for control of the metastatic niche: neutrophils versus monocytes
Published in
Breast Cancer Research, July 2012
DOI 10.1186/bcr3149
Pubmed ID
Authors

Jonathan B Mitchem, David G DeNardo

Abstract

ABSTRACT: Tumor-derived factors, such as proinflammatory cytokines, can increase the hospitality of metastatic sites by recruiting and activating leukocytes to perform supporting roles during metastatic dissemination. These same cytokines, however, are natural danger signals for the immune system and as such can induce anti-tumor immune responses by both adaptive and innate immune cells. The outcome of tumor-derived inflammatory cytokines is probably closely related to the exact repertoire of factors produced by each tumor. Several recent studies have investigated these seemingly contradictory roles of tumor-derived CCL2 with significant clinical implications.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
United States 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 41%
Researcher 4 18%
Student > Master 3 14%
Professor 2 9%
Student > Bachelor 2 9%
Other 1 5%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 36%
Medicine and Dentistry 6 27%
Biochemistry, Genetics and Molecular Biology 2 9%
Immunology and Microbiology 2 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2015.
All research outputs
#19,947,956
of 25,377,790 outputs
Outputs from Breast Cancer Research
#1,657
of 2,054 outputs
Outputs of similar age
#134,500
of 178,093 outputs
Outputs of similar age from Breast Cancer Research
#27
of 37 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,093 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.