Title |
Metabolic factors in osteoarthritis: obese people do not walk on their hands
|
---|---|
Published in |
Arthritis Research & Therapy, July 2012
|
DOI | 10.1186/ar3894 |
Pubmed ID | |
Authors |
Erlangga Yusuf |
Abstract |
ABSTRACT: Obesity is an important risk factor for the development and progression of osteoarthritis (OA). Recently, the paradigm that obesity predisposes people to OA because of extra-mechanical loading only has shifted to the paradigm that metabolic factors (adipokines) are also involved in the pathophysiology of OA. In a cross-sectional study in the previous issue of Arthritis Research & Therapy, Massengale and colleagues investigated the association between one of the adipokines - leptin - and hand OA. Hand joints are an ideal target to investigate the role of adipokines since they are not weight-bearing. Interestingly, no association with OA was found, bringing into question a metabolic, rather than a mechanical, explanation for the association between obesity and OA. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 31 | 22% |
United States | 15 | 10% |
Australia | 9 | 6% |
Canada | 7 | 5% |
Spain | 7 | 5% |
India | 4 | 3% |
Belgium | 3 | 2% |
New Zealand | 2 | 1% |
Malaysia | 2 | 1% |
Other | 16 | 11% |
Unknown | 48 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 120 | 83% |
Practitioners (doctors, other healthcare professionals) | 13 | 9% |
Scientists | 11 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Italy | 1 | 1% |
Unknown | 80 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 16% |
Researcher | 10 | 12% |
Student > Master | 10 | 12% |
Student > Postgraduate | 8 | 10% |
Student > Doctoral Student | 7 | 8% |
Other | 20 | 24% |
Unknown | 15 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 33% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Nursing and Health Professions | 7 | 8% |
Agricultural and Biological Sciences | 6 | 7% |
Engineering | 6 | 7% |
Other | 9 | 11% |
Unknown | 21 | 25% |