https://t.co/axT4dJYPJn "Ribavirin decreases expression of EZH2, Snail, total and phospho-eIF4E, cyclin D1, and phospho-mTOR in a time- and cell line–dependent manner."
https://t.co/axT4dJYPJn "Elevated IMPDH provides guanine nucleotides for rapidly dividing cells and has been implicated as a critical enzyme in cancer." "Protein expression of the IMPDH isoform IMPDH2 has been associated with aggressive features and poor
https://t.co/axT4dJYPJn "Finally, IMPDH is a biosynthetic enzyme involved in the conversion of inosine monophosphate to xanthosine monophosphate, the rate-limiting step in de novo synthesis of guanine nucleotides."
https://t.co/axT4dJYPJn "Another important feature of NPC is elevated protein expression of eIF4E, a critical effector of translation that has been associated with poor prognosis, drug resistance, and malignant transformation in approximately 30% of all c