Title |
Analysis of high dimensional data using pre-defined set and subset information, with applications to genomic data
|
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Published in |
BMC Bioinformatics, July 2012
|
DOI | 10.1186/1471-2105-13-177 |
Pubmed ID | |
Authors |
Wenge Guo, Mingan Yang, Chuanhua Xing, Shyamal D Peddada |
Abstract |
Based on available biological information, genomic data can often be partitioned into pre-defined sets (e.g. pathways) and subsets within sets. Biologists are often interested in determining whether some pre-defined sets of variables (e.g. genes) are differentially expressed under varying experimental conditions. Several procedures are available in the literature for making such determinations, however, they do not take into account information regarding the subsets within each set. Secondly, variables (e.g. genes) belonging to a set or a subset are potentially correlated, yet such information is often ignored and univariate methods are used. This may result in loss of power and/or inflated false positive rate. |
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Germany | 1 | 100% |
Demographic breakdown
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Germany | 1 | 3% |
Netherlands | 1 | 3% |
Brazil | 1 | 3% |
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United States | 1 | 3% |
Unknown | 26 | 84% |
Demographic breakdown
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Researcher | 11 | 35% |
Student > Ph. D. Student | 6 | 19% |
Professor > Associate Professor | 4 | 13% |
Student > Master | 3 | 10% |
Student > Bachelor | 2 | 6% |
Other | 4 | 13% |
Unknown | 1 | 3% |
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Mathematics | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Medicine and Dentistry | 2 | 6% |
Other | 0 | 0% |
Unknown | 1 | 3% |