@Christina_Wood1 @latkedelrey @ahandvanish @Mito_Q The amount of NAC likely to make any difference would be based upon weight (grams/day). eg. https://t.co/9EuZlJX16R "capsules of glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day, provided as N‐
RT @renesugar: "These antioxidants (mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC)) also prevented the upregulation of TNF-α…
RT @insulin_resista: تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/…
RT @insulin_resista: تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/…
تفاقم الامراض الفيروسية وخاصة التي تصيب الرئة وصعوبة السيطرة عليها لدى الناس الذين لديهم سكر٢ غير منضبط https://t.co/nHgfeuqfUq https://t.co/Z6NiNu0i7V
RT @ChrisMasterjohn: Monocytes are highly glycolytic: https://t.co/2zGI3BZR5k
Monocytes are highly glycolytic: https://t.co/2zGI3BZR5k
ORF3a 感染細胞apoptosis 癌退行か進行⬆️ https://t.co/vx7ILhJ2e2 免疫回避 https://t.co/Wu3WULD9L0 急性腎障害 https://t.co/HNeeJTjbPX 血糖値⬆️とHIF-1α https://t.co/8W2be3Qtg0
RT @ltkagohara: Insightful paper on why diabetes is a risk factor for COVID-19. Glucose increases virus replication and cytokines productio…
@WesElyMD @Nature May be of interest: https://t.co/4TAPQyEq0f
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/vnn4LOEd6i
@QuackDetector Lol, you must have the dumbest of followers. What are all they up to? 6th shot? https://t.co/42PnvYDLnq
@qtpocopony @MONTMAN9500 @suemidd58863059 @TheChiefNerd Here is another: https://t.co/D30Ygf8Ug5
Exploration of mechanisms helps explain complex scientific processes which convinces scientists, who truly believe in logic, of how one leads to another, what goes wrong during adverse conditions & how to fix them.Without knowing the mechanism, we cann
"These antioxidants (mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC)) also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α target genes" https://t.co/KyNnkGnBXV
RT @renesugar: https://t.co/MZNAuJOJZt "In conclusion, we showed that #SARSCoV2-infected monocytes express large amounts of proinflammator…
RT @renesugar: https://t.co/MZNAuJOJZt "These antioxidants also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α tar…
RT @renesugar: https://t.co/MZNAuJOJZt "Treatment of #SARSCoV2-infected monocytes with antioxidants, such as mitoquinol (MitoQ) or thiol r…
血糖値⬆️はHIF-1α/解糖依存軸 ⇨SARS-CoV-2感染と単球応答⬆️ https://t.co/OQQcuZA9UU 血糖値⬆️は単球における🦠複製とcytokine産生を調節 解糖系はコロナによる単球応答と🦠複製を維持 mtROS/HIF-1αはCoV-2複製と単球cytokine産生に必要 単球由来cytokineがT細胞の機能不全と上皮細胞死⬆️ https://t.co/zpsZ4Mh0Cc
https://t.co/MZNAuJOJZt "These data may explain why uncontrolled diabetes may lead to compromised adaptive immune response and lung dysfunction in patients with severe #COVID19 symptoms."
https://t.co/MZNAuJOJZt "Finally, we demonstrate that #SARSCoV2-infected monocytes promote T cell dysfunction and lung epithelial cell death."
https://t.co/MZNAuJOJZt "Glycolytic flux is required for #SARSCoV2 replication." #SARSCoV2-induced mtROS production stabilizes HIF-1α, which in turn upregulates glycolytic genes and IL-1β expression."
https://t.co/MZNAuJOJZt "In conclusion, we showed that #SARSCoV2-infected monocytes express large amounts of proinflammatory cytokines and IFNs." "Elevated glucose levels directly induce viral replication and proinflammatory cytokine expression."
https://t.co/MZNAuJOJZt "These results provide evidence to explain why elevated glucose levels during #SARSCoV2 infection may lead to T cell dysfunction and lymphopenia."
https://t.co/MZNAuJOJZt "CM-CoV-2 increased PD-1 expression by CD4 T cells, and this was reversed in CM-BAY87, CM-MitoQ, and CM-IL-1β"
https://t.co/MZNAuJOJZt "These antioxidants also prevented the upregulation of TNF-α; IL-6; IFN α, β, and λ; and HIF-1α target genes" "Persistent viral infections are associated with increased PD-1 expression, a marker of T cell exhaustion"
https://t.co/MZNAuJOJZt "Treatment of #SARSCoV2-infected monocytes with antioxidants, such as mitoquinol (MitoQ) or thiol reductant N-acetyl cysteine (NAC), was sufficient to inhibit viral replication and #SARSCoV2-induced HIF-1α stabilization and express
https://t.co/MZNAuJOJZt "HIF-1α-induced changes in monocyte metabolism by #SARSCoV2 infection directly inhibit T cell response and reduce epithelial cell survival." "Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs
https://t.co/MZNAuJOJZt "The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis."
https://t.co/MZNAuJOJZt "These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates #SARSCoV2 replication."
https://t.co/MZNAuJOJZt "Monocytes and macrophages are the most enriched immune cell types in the lungs of #COVID19 patients and appear to have a central role in the pathogenicity of the disease."
https://t.co/MZNAuJOJZt "- mtROS/HIF-1α is necessary for #SARSCoV2 replication and monocyte cytokine production - Monocyte-derived cytokines drive T cell dysfunction and epithelial cell death"
https://t.co/MZNAuJOJZt "- Elevated glucose levels regulate viral replication and cytokine production in monocytes - Glycolysis sustains #SARSCoV2-induced monocyte response and viral replication"
Elevated Glucose Levels Favor #SARSCoV2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/5VIFHGDrp7
RT @DrSunitKSingh: Connection between Glucose levels and COVID-19 Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response…
https://t.co/alRc65iJZv 「高グルコースレベルは、HIF-1α/解糖依存性の軸を通してSARS-CoV-2感染と単球応答を促進する」
https://t.co/alRc65iJZv 「SARS-CoV-2の感染と単球の反応にグルコースレベルの上昇がHIF-1α/解糖依存的に寄与していること」
@RolandBakerIII @loafingcactus Not really about the confounding, sorry From what I read, it has many times looked to me as if metforming would help modulating host response to infection, inhibiting mTOR, hence creating an hostile env for viral replication
@Operation_Ivy26 @thien3000 @DefiantLs Hmmm. Your lifestyle has a huge impact on your likelihood of contracting and there4 spreading covid. Covid selects for the glucose pathways, elevated in obese people. Your lifestyle can in fact make you a super-spread
RT @DrLBoominathan: 8. How do elevated Glucose Levels Favor SARS-CoV-2 Infection? Elevated Glucose levels, induce HIF1α, which in turn, ind…
@yaneerbaryam @CartlandDavid This study from 2020 found that elevated glucose levels increase susceptibility to SARS-CoV-2 through the HIF-1a pathway: https://t.co/3JDb69yiY9
RT @AleTrainerxxx: Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α.…
RT @AleTrainerxxx: Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α.…
Questi antiossidanti hanno anche impedito la sovra regolazione del TNF-α; IL-6; IFN α, β e λ; e geni bersaglio HIF-1α. ‼️👇 https://t.co/DhcqLPgrhn
@schmucksidyboy @2WaysToPlay @kevinbrownnc @DanCrenshawTX Don't tell me you didn't ask yourself why the obese are so overly represented? Gluttony most certainly is contagious when Covid selects for glucose. Basic concepts.......https://t.co/aIvSi4qP3k
RT @DorissLoh: Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
RT @DorissLoh: Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
Apparently, SARS-CoV-2 can upregulate glycolysis and suppress OXPHOS in mitochondria. 2/4 https://t.co/vUVfYOfavJ
Remember that COVID increases glucose overall via glycoprotein 73, increased release of cortisol, metabolic dysfunction, and changes in glycolysis and glycolytic pathway too. https://t.co/EJu6rmuk3F https://t.co/LwxT3gL2rd https://t.co/UJw8CYmvYt
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/1mSDNl2v7m
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
RT @BlackSanta911: @fynn_fan Top experts are fully aware that elevated blood glucose levels give SC2 the advantage of infection/replication…
“Government spends $4 BILLION every year subsidizing sugar production...” https://t.co/QqeEHbQui5
RT @mdeatherage76: 'Here we show that elevated glucose and sustained aerobic glycolysis in monocytes directly promote viral replication, cy…
Also stay away from carbs. Increases your chance of COVID infection and serious disease.
@ZubyMusic @dan_janky Obesity is contagious - literally - in the context of covid. "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - eating habits affect transmissibility and contagiousness. It's why the obese/diabetics were overly represented. https:
@Tanto_Archilo @DarrenJBeattie "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - in the context of Covid eating habits certainly affect transmissibility and contribute to the pandemic. Surely you wondered why the obese were overly represented? https:/
RT @tom_sarega: @AIWinGold @Tamara_uni @abiroberts "Elevated Glucose Levels Favor SARS-CoV-2 Infection". The context discussed is covid. In…
@AIWinGold @Tamara_uni @abiroberts "Elevated Glucose Levels Favor SARS-CoV-2 Infection". The context discussed is covid. In that context eating habits definitely affect contagiousness of the disease - that's why they're over-represented. https://t.co/FmwtQ
@StephanKesting Something to consider to reduce the odds...might be worth a deep dive. Also goes hand in hand with our obesity discussion. Good luck, https://t.co/ck7BDoGcCn
"HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival" https://t.co/1mSDNl2v7m https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW @DrLBoominathan
https://t.co/1mSDNl2v7m "The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis." https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW @DrLBoominathan
2/3 Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis https://t.co/1mSDNl2v7m @RiceLaboratory @KannegantiLab, @KroganLab, @thechandalab, @Cambridge_COGUK https://t.co/mSTcmbgL93
RT @isa_picard: Une diète riche en sucre un facteur prédisposant a une moins bonne réponse immunitaire? L’influence negative d’une diète ri…
Une diète riche en sucre un facteur prédisposant a une moins bonne réponse immunitaire? L’influence negative d’une diète riche en sucre a déjà été observée sur la réponse immunitaire générale https://t.co/7RHj34Mmek et meme covid https://t.co/XKe6Cb4SvU et
@Jopo_dr Your thread is very interesting! Perhaps tangent to your thread: Could we be more endangered by a virus or bacteria that adapted to the rhythmic biological processes of a nocturnal reservoir? Thread: https://t.co/vhNV0wS9de https://t.co/3kObU9v
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
https://t.co/MZNAuJwALl "- Elevated glucose levels regulate viral replication and cytokine production in monocytes - Glycolysis sustains #SARSCoV2-induced monocyte response and viral replication - mtROS/HIF-1α is necessary for CoV-2 replication and monocy
@BroadwayVincenz @rmastersnest @TolstoyKarenina @ChanceTyColeman "Elevated Glucose Levels Favor SARS-CoV-2 Infection" - in the context of Covid eating habits certainly affect transmissibility. https://t.co/FmwtQHhxpB
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
@Canad_IANism @drmikehart @Sotacor Elevated Glucose Levels Favor SARS-CoV-2 Infection' - eating habits quite literally impact contagiousness in the context of covid. https://t.co/FmwtQHhxpB
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @WorldEdgeDG: I literally forgot the most important part, the reason I decided to write this lmao. https://t.co/iTehIls7TW
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.
RT @gutwat1: This isn’t takes about enough Limit your sugar intake. https://t.co/03KTJYmraa
RT @gutwat1: This isn’t takes about enough Limit your sugar intake.