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Distinct alterations in motor

Overview of attention for article published in Brain, Behavior & Immunity, July 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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16 tweeters
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1 Facebook page

Citations

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44 Dimensions

Readers on

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118 Mendeley
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Title
Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation
Published in
Brain, Behavior & Immunity, July 2017
DOI 10.1016/j.bbi.2016.06.002
Pubmed ID
Authors

Megan E. Straley, Wesley Van Oeffelen, Sarah Theze, Aideen M. Sullivan, Siobhain M. O’Mahony, John F. Cryan, Gerard W. O’Keeffe

Abstract

The dopaminergic system is involved in motivation, reward and the associated motor activities. Mesodiencephalic dopaminergic neurons in the ventral tegmental area (VTA) regulate motivation and reward, whereas those in the substantia nigra (SN) are essential for motor control. Defective VTA dopaminergic transmission has been implicated in schizophrenia, drug addiction and depression whereas dopaminergic neurons in the SN are lost in Parkinson's disease. Maternal immune activation (MIA) leading to in utero inflammation has been proposed to be a risk factor for these disorders, yet it is unclear how this stimulus can lead to the diverse disturbances in dopaminergic-driven behaviors that emerge at different stages of life in affected offspring. Here we report that gestational age is a critical determinant of the subsequent alterations in dopaminergic-driven behavior in rat offspring exposed to lipopolysaccharide (LPS)-induced MIA. Behavioral analysis revealed that MIA on gestational day 16 but not gestational day 12 resulted in biphasic impairments in motor behavior. Specifically, motor impairments were evident in early life, which were resolved by adolescence, but subsequently re-emerged in adulthood. In contrast, reward seeking behaviors were altered in offspring exposed MIA on gestational day 12. These changes were not due to a loss of dopaminergic neurons per se in the postnatal period, suggesting that they reflect functional changes in dopaminergic systems. This highlights that gestational age may be a key determinant of how MIA leads to distinct alterations in dopaminergic-driven behavior across the lifespan of affected offspring.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Russia 1 <1%
Unknown 116 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 20%
Student > Master 19 16%
Researcher 12 10%
Student > Bachelor 12 10%
Student > Doctoral Student 10 8%
Other 21 18%
Unknown 20 17%
Readers by discipline Count As %
Neuroscience 24 20%
Psychology 21 18%
Medicine and Dentistry 15 13%
Agricultural and Biological Sciences 8 7%
Biochemistry, Genetics and Molecular Biology 7 6%
Other 16 14%
Unknown 27 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2018.
All research outputs
#3,573,539
of 22,876,619 outputs
Outputs from Brain, Behavior & Immunity
#936
of 3,117 outputs
Outputs of similar age
#64,139
of 313,623 outputs
Outputs of similar age from Brain, Behavior & Immunity
#17
of 48 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,117 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.