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Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent

Overview of attention for article published in BMC Biotechnology, January 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

dimensions_citation
4 Dimensions

Readers on

mendeley
21 Mendeley
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Title
Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent
Published in
BMC Biotechnology, January 2012
DOI 10.1186/1472-6750-12-43
Pubmed ID
Authors

Ming-Chuan Li, Qian-Qian Liu, Xiao-Yun Lu, Ya-Li Zhang, Lei-Lei Wang

Abstract

Costimulation of T cells via costimulatory molecules such as B7 is important for eliciting cell-mediated antitumor immunity. Presenting costimulation molecules by immobilizing recombinant B7 on the surface of nanovectors is a novel strategy for complementary therapy. Polyhydroxyalkanoates (PHAs) are a family of biodegradable, non-toxic, biocompatible polyesters, which can be used as a nonspecific immobilizing matrix for protein presentation. Recombinant protein fusion with PHA granule binding protein phasin (PhaP) can be easily immobilized on the surface of PHA nanoparticles through hydrophobic interactions between PhaP and PHA, and therefore provides a low-cost protein presenting strategy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 5%
Unknown 20 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 38%
Student > Bachelor 3 14%
Researcher 3 14%
Student > Doctoral Student 2 10%
Student > Master 2 10%
Other 2 10%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 43%
Immunology and Microbiology 3 14%
Engineering 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Environmental Science 1 5%
Other 0 0%
Unknown 5 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2013.
All research outputs
#3,344,714
of 12,373,386 outputs
Outputs from BMC Biotechnology
#252
of 695 outputs
Outputs of similar age
#31,483
of 121,331 outputs
Outputs of similar age from BMC Biotechnology
#3
of 7 outputs
Altmetric has tracked 12,373,386 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 695 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,331 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.