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Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines

Overview of attention for article published in BMC Molecular Biology, July 2012
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2 tweeters

Citations

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12 Dimensions

Readers on

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24 Mendeley

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Title
Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines
Published in
BMC Molecular Biology, July 2012
DOI 10.1186/1471-2199-13-25
Pubmed ID
22846052
Authors

Trinidad Mata Balaguer, Angeles Gómez-Martínez, Pilar García-Morales, Javier Lacueva, Rafael Calpena, Lourdes Rocamora Reverte, Natividad Lopez Riquelme, Isabel Martinez-Lacaci, José A Ferragut, Miguel Saceda

Abstract

It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise the use of iHDACs in combination with other cytotoxic agents that are substrates of P-glycoprotein (Pgp). It has also been reported the use of alternative promoters by the ABCB1 gene and the existence of a translational control of Pgp protein. Finally, the ABCB1 gene is located in a genetic locus with the nested gene RUNDC3B in the complementary DNA strand, raising the possibility that RUNDC3B expression could interfere with ABCB1 alternative promoter regulation.

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Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 2 8%
United States 1 4%
Unknown 21 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Ph. D. Student 3 13%
Student > Doctoral Student 2 8%
Student > Bachelor 2 8%
Student > Master 2 8%
Other 3 13%
Unknown 5 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 42%
Medicine and Dentistry 3 13%
Biochemistry, Genetics and Molecular Biology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 7 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2012.
All research outputs
#9,508,011
of 12,372,276 outputs
Outputs from BMC Molecular Biology
#170
of 249 outputs
Outputs of similar age
#83,098
of 121,937 outputs
Outputs of similar age from BMC Molecular Biology
#2
of 2 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 249 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,937 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.

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