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Statistical methods for identifying differentially expressed genes in RNA-Seq experiments

Overview of attention for article published in Cell & Bioscience, July 2012
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Title
Statistical methods for identifying differentially expressed genes in RNA-Seq experiments
Published in
Cell & Bioscience, July 2012
DOI 10.1186/2045-3701-2-26
Pubmed ID
Authors

Zhide Fang, Jeffrey Martin, Zhong Wang

Abstract

RNA sequencing (RNA-Seq) is rapidly replacing microarrays for profiling gene expression with much improved accuracy and sensitivity. One of the most common questions in a typical gene profiling experiment is how to identify a set of transcripts that are differentially expressed between different experimental conditions. Some of the statistical methods developed for microarray data analysis can be applied to RNA-Seq data with or without modifications. Recently several additional methods have been developed specifically for RNA-Seq data sets. This review attempts to give an in-depth review of these statistical methods, with the goal of providing a comprehensive guide when choosing appropriate metrics for RNA-Seq statistical analyses.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 311 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 3%
Spain 3 <1%
Brazil 2 <1%
Germany 2 <1%
Argentina 2 <1%
United Kingdom 1 <1%
Canada 1 <1%
Mexico 1 <1%
Cuba 1 <1%
Other 4 1%
Unknown 286 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 74 24%
Researcher 67 22%
Student > Master 44 14%
Student > Bachelor 34 11%
Student > Doctoral Student 14 5%
Other 33 11%
Unknown 45 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 151 49%
Biochemistry, Genetics and Molecular Biology 50 16%
Mathematics 11 4%
Medicine and Dentistry 10 3%
Computer Science 8 3%
Other 30 10%
Unknown 51 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2012.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Cell & Bioscience
#956
of 1,177 outputs
Outputs of similar age
#161,223
of 178,869 outputs
Outputs of similar age from Cell & Bioscience
#7
of 7 outputs
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