Title |
Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb/c mice: combination with phytochemical composition
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Published in |
BMC Complementary Medicine and Therapies, July 2012
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DOI | 10.1186/1472-6882-12-111 |
Pubmed ID | |
Authors |
Dalel Brahmi, Yousra Ayed, Mbarka Hfaiedh, Chayma Bouaziz, Hedi Ben Mansour, Lazhar Zourgui, Hassen Bacha |
Abstract |
Cis-Platinum (II) (cis-diammine dichloroplatinum; CDDP) is a potent antitumor compound widely used for the treatment of many malignancies. An important side-effect of CDDP is nephrotoxicity. The cytotoxic action of this drug is often thought to induce oxidative stress and be associated with its ability to bind DNA to form CDDP-DNA adducts and apoptosis in kidney cells. In this study, the protective effect of cactus cladode extract (CCE) against CDDP-induced oxidative stress and genotoxicity were investigated in mice. We also looked for levels of malondialdehyde (MDA), catalase activity, superoxide dismutase (SOD) activity, chromosome aberrations (CA) test, SOS Chromotest, expressions of p53, bax and bcl2 in kidney and we also analyzed several parameters of renal function markers toxicity such as serum biochemical analysis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 20% |
Researcher | 8 | 18% |
Student > Master | 6 | 13% |
Student > Doctoral Student | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 7 | 16% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 22% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Veterinary Science and Veterinary Medicine | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Other | 8 | 18% |
Unknown | 11 | 24% |