Title |
Characterization of Cold Sensitivity and Thermal Preference Using an Operant Orofacial Assay
|
---|---|
Published in |
Molecular Pain, December 2006
|
DOI | 10.1186/1744-8069-2-37 |
Pubmed ID | |
Authors |
Heather L Rossi, Charles J Vierck, Robert M Caudle, John K Neubert |
Abstract |
A hallmark of many orofacial pain disorders is cold sensitivity, but relative to heat-related pain, mechanisms of cold perception and the development of cold allodynia are not clearly understood. Molecular mediators of cold sensation such as TRPM8 have been recently identified and characterized using in vitro studies. In this study we characterized operant behavior with respect to individually presented cold stimuli (24, 10, 2, and -4 degrees C) and in a thermal preference task where rats chose between -4 and 48 degrees C stimulation. We also evaluated the effects of menthol, a TRPM8 agonist, on operant responses to cold stimulation (24, 10, and -4 degrees C). Male and female rats were trained to drink sweetened milk while pressing their shaved faces against a thermode. This presents a conflict paradigm between milk reward and thermal stimulation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 30% |
Researcher | 10 | 20% |
Student > Ph. D. Student | 8 | 16% |
Professor > Associate Professor | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 6 | 12% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 38% |
Agricultural and Biological Sciences | 9 | 18% |
Neuroscience | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 6 | 12% |
Unknown | 8 | 16% |