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The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1

Overview of attention for article published in Allergy, July 2016
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Title
The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1
Published in
Allergy, July 2016
DOI 10.1111/all.12955
Pubmed ID
Authors

D. Apostolovic, S. Sánchez‐Vidaurre, K. Waden, M. Curin, J. Grundström, G. Gafvelin, T. Cirkovic Velickovic, H. Grönlund, W. R. Thomas, R. Valenta, C. Hamsten, M. van Hage

Abstract

We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenicity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE-binding to rCan f 1 in 4/13 patients, whereas rCan f 1 inhibited IgE-binding to rFel d 7 in 7/13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found by using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients. This article is protected by copyright. All rights reserved.

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Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 36%
Other 2 8%
Student > Ph. D. Student 2 8%
Librarian 1 4%
Unspecified 1 4%
Other 3 12%
Unknown 7 28%
Readers by discipline Count As %
Immunology and Microbiology 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Medicine and Dentistry 3 12%
Agricultural and Biological Sciences 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Other 1 4%
Unknown 9 36%