Title |
The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1
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Published in |
Allergy, July 2016
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DOI | 10.1111/all.12955 |
Pubmed ID | |
Authors |
D. Apostolovic, S. Sánchez‐Vidaurre, K. Waden, M. Curin, J. Grundström, G. Gafvelin, T. Cirkovic Velickovic, H. Grönlund, W. R. Thomas, R. Valenta, C. Hamsten, M. van Hage |
Abstract |
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenicity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE-binding to rCan f 1 in 4/13 patients, whereas rCan f 1 inhibited IgE-binding to rFel d 7 in 7/13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found by using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 36% |
Other | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Librarian | 1 | 4% |
Unspecified | 1 | 4% |
Other | 3 | 12% |
Unknown | 7 | 28% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 5 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 16% |
Medicine and Dentistry | 3 | 12% |
Agricultural and Biological Sciences | 2 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 1 | 4% |
Unknown | 9 | 36% |