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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunoglobulin class-switch recombination deficiencies
|
|---|---|
| Published in |
Arthritis Research & Therapy, July 2012
|
| DOI | 10.1186/ar3904 |
| Pubmed ID | |
| Authors |
Anne Durandy, Sven Kracker |
| Abstract |
ABSTRACT: Immunoglobulin class-switch recombination deficiencies (Ig-CSR-Ds) are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect in question, the Ig-CSR-D may be combined with an impairment in somatic hypermutation (SHM). Some of the mechanisms underlying Ig-CSR and SHM have been described by studying natural mutants in humans. This approach has revealed that T cell-B cell interaction (resulting in CD40-mediated signaling), intrinsic B-cell mechanisms (activation-induced cytidine deaminase-induced DNA damage), and complex DNA repair machineries (including uracil-N-glycosylase and mismatch repair pathways) are all involved in class-switch recombination and SHM. However, several of the mechanisms required for full antibody maturation have yet to be defined. Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 11% |
| Ecuador | 1 | 11% |
| Spain | 1 | 11% |
| France | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 27% |
| Student > Ph. D. Student | 13 | 19% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 4 | 6% |
| Lecturer | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 18 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 19% |
| Immunology and Microbiology | 11 | 16% |
| Agricultural and Biological Sciences | 10 | 15% |
| Medicine and Dentistry | 9 | 13% |
| Mathematics | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 20 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2023.
All research outputs
#3,249,412
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#683
of 3,381 outputs
Outputs of similar age
#21,460
of 179,587 outputs
Outputs of similar age from Arthritis Research & Therapy
#9
of 45 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,587 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.