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Mendeley readers
Attention Score in Context
| Title |
Ulk4 Regulates Neural Stem Cell Pool
|
|---|---|
| Published in |
Stem Cells, June 2016
|
| DOI | 10.1002/stem.2423 |
| Pubmed ID | |
| Authors |
Min Liu, Zhenlong Guan, Qin Shen, Frances Flinter, Laura Domínguez, Joo Wook Ahn, David A. Collier, Timothy O'Brien, Sanbing Shen |
| Abstract |
The size of neural stem cell (NSC) pool at birth determines the starting point of adult neurogenesis. Aberrant neurogenesis is associated with major mental illness, in which ULK4 is proposed as a rare risk factor. Little is known about factors regulating the NSC pool, or function of the ULK4. Here we showed that Ulk4(tm1a/tm1a) mice displayed a dramatically reduced NSC pool at birth. Ulk4 was expressed in a cell cycle-dependent manner and peaked in G2/M phases. Targeted disruption of the Ulk4 perturbed mid-neurogenesis and significantly reduced cerebral cortex in postnatal mice. Pathway analyses of dysregulated genes in Ulk4(tm1a/tm1a) mice revealed Ulk4 as a key regulator of cell cycle and NSC proliferation, partially through regulation of the Wnt signaling. In addition we identified hemizygous deletion of ULK4 gene in 1.2/1000 patients with pleiotropic symptoms including severe language delay and learning difficulties. ULK4, therefore, may significantly contribute to neurodevelopmental, neuropsychiatric and neurodegenerative disorders. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 6 | 22% |
| Student > Doctoral Student | 5 | 19% |
| Student > Ph. D. Student | 5 | 19% |
| Researcher | 4 | 15% |
| Student > Bachelor | 3 | 11% |
| Other | 1 | 4% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 8 | 30% |
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Medicine and Dentistry | 5 | 19% |
| Agricultural and Biological Sciences | 4 | 15% |
| Unspecified | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 2 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2016.
All research outputs
#12,960,778
of 22,877,793 outputs
Outputs from Stem Cells
#2,918
of 3,902 outputs
Outputs of similar age
#177,320
of 352,119 outputs
Outputs of similar age from Stem Cells
#55
of 82 outputs
Altmetric has tracked 22,877,793 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,902 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,119 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.