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Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi

Overview of attention for article published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, June 2016
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Title
Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi
Published in
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, June 2016
DOI 10.1590/s1984-29612016036
Pubmed ID
Authors

Torres, Mariana de Medeiros, Almeida, Arleana do Bom Parto Ferreira de, Paula, Daphine Ariadne Jesus de, Mendonça, Adriane Jorge, Nakazato, Luciano, Pescador, Caroline Argenta, Sousa, Valéria Régia Franco

Abstract

Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman's rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs.

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Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 18%
Student > Postgraduate 1 9%
Unknown 8 73%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 9%
Agricultural and Biological Sciences 1 9%
Chemistry 1 9%
Unknown 8 73%