Title |
Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age
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Published in |
BMC Gastroenterology, November 2010
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DOI | 10.1186/1471-230x-10-140 |
Pubmed ID | |
Authors |
Shawn A Ritchie, Doug Heath, Yasuyo Yamazaki, Bryan Grimmalt, Amir Kavianpour, Kevin Krenitsky, Hoda Elshoni, Ichiro Takemasa, Masakazu Miyake, Mitsugu Sekimoto, Morito Monden, Takeshi Tomonaga, Hisahiro Matsubara, Kazuyuki Sogawa, Kazuyuki Matsushita, Fumio Nomura, Dayan B Goodenowe |
Abstract |
Serum levels of novel hydroxy polyunsaturated ultra long-chain fatty acids (hPULCFAs) have been previously shown to be reduced in pre-treatment CRC patients compared to disease-free subjects, independent of disease stage. However, whether reduced levels of hPULCFAs result from the presence of cancer is currently unknown, as is the distribution of hPULCFAs in the general population. The following studies were carried out to assess whether conventional therapy would result in restoration of systemic hPULCFAs in CRC patients, and to investigate the relationship between hPULCFA levels and age. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 22% |
Student > Ph. D. Student | 11 | 22% |
Student > Master | 5 | 10% |
Student > Bachelor | 5 | 10% |
Other | 3 | 6% |
Other | 6 | 12% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 30% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Chemistry | 5 | 10% |
Agricultural and Biological Sciences | 5 | 10% |
Computer Science | 2 | 4% |
Other | 6 | 12% |
Unknown | 11 | 22% |