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Efficacy of lactulose in the prophylaxis of hepatic encephalopathy in cirrhotic patients presenting gastrointestinal bleeding

Overview of attention for article published in Revista da Associação Médica Brasileira, June 2016
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Title
Efficacy of lactulose in the prophylaxis of hepatic encephalopathy in cirrhotic patients presenting gastrointestinal bleeding
Published in
Revista da Associação Médica Brasileira, June 2016
DOI 10.1590/1806-9282.62.03.243
Pubmed ID
Authors

Felipe Toyama Aires, Paola Teruya Ramos, Wanderley Marques Bernardo

Abstract

Hepatic encephalopathy (HE) is a bad prognostic factor in patients with liver cirrhosis and its incidence is associated with several triggering factors being the most prevalent gastrointestinal bleeding. Lactulose, despite its questionable efficacy in the literature, is considered a first line treatment in patients with HE. To evaluate the effectiveness of lactulose in preventing HE in cirrhotic patients with gastrointestinal bleeding. A systematic review of the literature using the Medline scientific database. Only randomized controlled clinical trials evaluating the efficacy of lactulose for HE prophylaxis in cirrhotic patients with gastrointestinal bleeding were included. The incidence of HE in the intervention group was 7%, while the control group was 26% (p=0.01). There was no significant difference in the incidence of mortality in the group treated with lactulose compared to the group that was not treated (p=0.48). Administering lactulose to cirrhotic patients with upper gastrointestinal bleeding reduces the incidence of hepatic encephalopathy.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 21%
Other 8 17%
Student > Master 5 10%
Student > Doctoral Student 3 6%
Researcher 3 6%
Other 8 17%
Unknown 11 23%
Readers by discipline Count As %
Medicine and Dentistry 21 44%
Pharmacology, Toxicology and Pharmaceutical Science 7 15%
Biochemistry, Genetics and Molecular Biology 2 4%
Nursing and Health Professions 2 4%
Immunology and Microbiology 1 2%
Other 3 6%
Unknown 12 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2016.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Revista da Associação Médica Brasileira
#807
of 1,105 outputs
Outputs of similar age
#309,351
of 353,651 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#14
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,105 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,651 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.