Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

Sars https://t.co/tm03jy6PgS

Covid 19 the Deletion Gene was reported or August 14th 2020. the deletion Gene was in Singapore and other countries before it struck Britain:https://t.co/blcU8rwmqC:

@bmiras @NicolasMeilhan Ah oui, elle est où votre étude ? Je l’attends de pied ferme. La DYNAMIQUE hein, pas le pic, allez-y. Parce que la relation de causalité entre mutation et gravité, Raoult l’avait lui. C’était cette étude sa référence. https://t.

11.2/x Con't quoting, “The clinical effect of DELETIONS in this region [#ORF8] appears to be a ***MILDER INFECTION WITH LESS SYSTEMIC RELEASE OF PROINFLAMMATORY CYTOKINES*** .” https://t.co/pmA8qSv0Eu

11/x Effects of a major deletion in SARS-CoV-2 genome on severity of infection and inflammatory response.. Quoting, “SARS-CoV-2 variants with a ..DELETION (∆382) in ..ORF8 ..detected in S’pore and other countries..." > https://t.co/6x3Vg4PU3h

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @BangoBilly: @rebeccabutlerm2 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT…

RT @BangoBilly: @rebeccabutlerm2 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT…

RT @BangoBilly: @rebeccabutlerm2 @s8mb @FatEmperor @toadmeister @JamesDelingpole "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE S…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

@footmanager2020 @Fabien_L https://t.co/C3kpPGLAfR

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

i would add that those in fear want to contol the narrative of fear as a means to justify their misplaced emotion

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

Like the common cold... ?

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

@OxLiving @wiltshire @naomirwolf https://t.co/p6yueRHo3j

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

RT @Kevin_McKernan: @monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental…

@monaghaaskycom1 @wiltshire @naomirwolf Some people want to be scared and shame all those that don’t share their mental illness. New variant is less virulent. It’s more rapid spread is likely stochastic and meaningless. https://t.co/PjhYadcgpo

RT @BangoBilly: @rebeccabutlerm2 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT…

@FatEmperor @rwmed1974 @EssexPR @WolbersBart @essentialjc @ToniaBuxton @ClareCraigPath @Stat_O_Guy @MichaelYeadon3 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@DPJHodges "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@rebeccabutlerm2 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@rebeccabutlerm2 @s8mb @FatEmperor @toadmeister @JamesDelingpole "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@s8mb "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@s8mb "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@EmergencyBod @s8mb "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

RT @You3_JP: 新しい英国の変異種B.1.1.7は、変異したORF8の遺伝子を有する。 変異種は、実は以前から存在していたものであり、アフリカ、フランス、およびシンガポールでは毒性、致死性が弱まっていた。ウィルスに罹患した者は酸素補給を必要とすることはなかった。 ど…

Sars https://t.co/tm03jy6PgS

4/ This may also indicate reduced pathogenicity, consistent with the deletion of ORF8 (see https://t.co/gQt2SClmae. They are also doing virology on infectivity and viral yield in vitro and in vivo. This must be disclosed as soon as results known @deb_cohe

@alistairtyrrell @adamfleming I hope this helps reassure you. https://t.co/NrSocRhABu https://t.co/a5GTQU4pPd https://t.co/BTjrNWOcJN Rgds

@nishmcnish @NickTriggle nishmcnnish8. I hope this helps reassure you. https://t.co/NrSocRhABu https://t.co/0A9QdJFbM0 https://t.co/a5GTQU4pPd https://t.co/BTjrNWOcJN Rgds

X https://t.co/YBqyeFgH5A

RT @Thomas_Wilckens: Maybe we need even less #vaccination #COVID19 https://t.co/kjGYgKUJlX

Maybe we need even less #vaccination #COVID19

@BallouxFrancois @profvrr @Adam_Creighton @JuliaHB1 @Thomas_Wilckens @SHomburg @MichaelYeadon3 @ClareCraigPath @jengleruk 9.4.2/x Con’t quoting, “The clinical effect of DELETIONS in this region [#ORF8] appears to be a MILDER INFECTION WITH LESS SYSTEMIC

@BallouxFrancois @profvrr @Adam_Creighton @JuliaHB1 @Thomas_Wilckens @SHomburg @MichaelYeadon3 @ClareCraigPath @jengleruk 9.4/x Ref by Lucy van Dorp (see tweet 9.3) Effects of a major deletion in SARS-CoV-2 genome on severity of infection and inflammatory

RT @ncholiA: @yoncabulutmd @fitterhappierAJ @genperisi @ArditiMd @ManishButte What I learned about SARS-viruses (SARS1/2 closely related) i…

RT @ncholiA: @yoncabulutmd @fitterhappierAJ @genperisi @ArditiMd @ManishButte What I learned about SARS-viruses (SARS1/2 closely related) i…

@yoncabulutmd @fitterhappierAJ @genperisi @ArditiMd @ManishButte What I learned about SARS-viruses (SARS1/2 closely related) in 2018: ORF8 mutations are bad for the virus.😈[https://t.co/5onZE0Fn6X] This has also been confirmed by an observational cohort s

@yoncabulutmd @fitterhappierAJ https://t.co/06IBDpJKgC

@MarionKoopmans Ook in the UK variant is er een ‘nucleotide deletion in the open reading frame 8 (ORF8) and this seems to be associated with a milder infection.’ Een verminderde kans op het ontwikkelen van hypoxia. Waarom zegt u daar niets over? https://t

@matfieldaj @cricketwyvern https://t.co/W0IJtbTZbn

RT @Kevin_McKernan: @friesdan It's not novel. It been in other jurisdictions. @BallouxFrancois has posted about this. The ORF8 deletion pa…

@friesdan It's not novel. It been in other jurisdictions. @BallouxFrancois has posted about this. The ORF8 deletion paper is here. Suggestive of it being less virulent. https://t.co/PjhYadcgpo

RT @You3_JP: 新しい英国の変異種B.1.1.7は、変異したORF8の遺伝子を有する。 変異種は、実は以前から存在していたものであり、アフリカ、フランス、およびシンガポールでは毒性、致死性が弱まっていた。ウィルスに罹患した者は酸素補給を必要とすることはなかった。 ど…

@welt Totaler Blödsinn. Vielleicht infektöser, aber nicht tödlicher. Schade, dass es unabhängige Wissenschaftlicher gibt, die Fakten untersuchen, oder? https://t.co/oPqs9c0xRk

RT @nrwno: Seems this new variant is far less deadly. But they still want lock downs! Bet the government really want to stop the spread o…

RT @mipardudire: 6/6 Como siempre dejo bibliografia para cotejar los datos y de paso informarse sobre el Orf8 como su mejor pronóstico clin…

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…

@janemerrick23 https://t.co/Uc4xOyQZA0

@NancyCounts "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@NancyCounts @DanCardenMP "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@fmwales "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@fmwales "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@Wokeman8 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

RT @PrNickGay: It has a null mutation in ORF8 which is associated with lower odds of developing hypoxia requiring supplemental oxygen. ORF8…

It has a null mutation in ORF8 which is associated with lower odds of developing hypoxia requiring supplemental oxygen. ORF8 functions by inhibiting trafficking of MHC-1 to the cell surface, down regulating CD8+ T-cells and inhibiting interferon responses.

@DanCardenMP "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@cjsnowdon @VanessaGray999 "LOCKDOWN IMPEDES THIS NATURAL WEAKENING" NOBEL LAUREATE SCIENCE PRIZE WINNER === PROFESSOR MICHAEL LEVITT === https://t.co/W0IJtbTZbn

@OmicsOmicsBlog @pcrclaims @Rational_Ground @PanData19 Another topic that would benefit from qPCR transparency. Otherwords we will have to live with the Lancet. https://t.co/PjhYadcgpo https://t.co/AhgvRDUBQT

RT @LilyBorahae: While the new strain contains many changes, this particular one appears to be trending more infectious yet potentially les…

Sars https://t.co/tm03jy6PgS

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @BallouxFrancois: A recent paper reports evidence that #SARSCoV2 strains with large deletions in one of its genes (ORF8) cause milder in…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @You3_JP: 新しい英国の変異種B.1.1.7は、変異したORF8の遺伝子を有する。 変異種は、実は以前から存在していたものであり、アフリカ、フランス、およびシンガポールでは毒性、致死性が弱まっていた。ウィルスに罹患した者は酸素補給を必要とすることはなかった。 ど…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @MLevitt_NP2013: Is SARS-CoV-2 mutating to be less lethal? @TheLancet says so https://t.co/m0nkSYBuay. Was told this happens by the viro…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

RT @Kevin_McKernan: @NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a…

@NateSilver538 @trvrb It has an ORF8 deletion making it less virulent. Transmission of a less virulent strain is like a free vax...only we understand the risk of the virus far better than the vax at the moment. Vax is subsidized with no liability. Might pr

RT @MLevitt_NP2013: Is SARS-CoV-2 mutating to be less lethal? @TheLancet says so https://t.co/m0nkSYBuay. Was told this happens by the viro…

RT @MLevitt_NP2013: Is SARS-CoV-2 mutating to be less lethal? @TheLancet says so https://t.co/m0nkSYBuay. Was told this happens by the viro…

RT @MLevitt_NP2013: Is SARS-CoV-2 mutating to be less lethal? @TheLancet says so https://t.co/m0nkSYBuay. Was told this happens by the viro…

(2) Variant is less pathogenic, deletion of ORF8, one of the mutations, is associated with lower odds of developing hypoxia https://t.co/gQt2SClmae, larger numbers need hospital treatment but survive.

@NicolaSturgeon https://t.co/3Rf6ri5ijp

@BlauweLotus @umarebru Wellicht “ultrabesmettelijk” en zeer waarschijnlijk minder heftig. Dat vermeld je er niet bij, want dat past niet in het narratief hè? Weet je wat ook een heel besmettelijk virus is? Het Rhinovirus. Moet daarvoor nu dan ook een maske

RT @BpsmithUk: In ~1wk we'll know if its true for "UK variant". "Our" strain has dozens of mutations not seen together before. People say "…

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…

RT @mipardudire: 6/6 Como siempre dejo bibliografia para cotejar los datos y de paso informarse sobre el Orf8 como su mejor pronóstico clin…

RT @kaggieguy: The "new" British variant B.1.1.7 has a mutated ORF8 gene. These mutations have been seen previously, and were less virulen…