Title |
Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis
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Published in |
Diagnostic Pathology, August 2012
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DOI | 10.1186/1746-1596-7-97 |
Pubmed ID | |
Authors |
Leandro Luongo de Matos, Adriana Braz Del Giglio, Carolina Ogawa Matsubayashi, Michelle de Lima Farah, Auro Del Giglio, Maria Aparecida da Silva Pinhal |
Abstract |
To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. In an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistochemistry techniques have been studied, mainly cytokeratin-19 (CK-19), galectin-3 (Gal-3) and Hector Battifora mesothelial-1 (HBME-1). However, current results remain controversial. The aim of the present article was to establish the diagnostic accuracy of CK-19, Gal-3 and HBME-1 markers, as well as their associations, in the differentiation of malignant and benign thyroid lesions. |
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