Title |
Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder
|
---|---|
Published in |
Behavioral and Brain Functions, June 2016
|
DOI | 10.1186/s12993-016-0102-3 |
Pubmed ID | |
Authors |
Jacqueline S. Womersley, Bafokeng Mpeta, Jacqueline J. Dimatelis, Lauriston A. Kellaway, Dan J. Stein, Vivienne A. Russell |
Abstract |
Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains. Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats. Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 16% |
Professor | 5 | 14% |
Student > Ph. D. Student | 5 | 14% |
Student > Doctoral Student | 3 | 8% |
Student > Master | 3 | 8% |
Other | 8 | 22% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 5 | 14% |
Psychology | 5 | 14% |
Agricultural and Biological Sciences | 4 | 11% |
Medicine and Dentistry | 3 | 8% |
Business, Management and Accounting | 2 | 5% |
Other | 9 | 24% |
Unknown | 9 | 24% |