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Dystrophic neurites express C9orf72 in Alzheimer's disease brains

Overview of attention for article published in Alzheimer's Research & Therapy, August 2012
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 X user
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6 patents

Citations

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20 Dimensions

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65 Mendeley
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Title
Dystrophic neurites express C9orf72 in Alzheimer's disease brains
Published in
Alzheimer's Research & Therapy, August 2012
DOI 10.1186/alzrt136
Pubmed ID
Authors

Jun-ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arima

Abstract

Chromosome 9 open reading frame 72 (C9orf72) is an evolutionarily conserved protein with unknown function, expressed at high levels in the brain. An expanded hexanucleotide GGGGCC repeat located in the first intron of the C9orf72 gene represents the most common genetic cause of familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Previous studies by immunohistochemistry with two different anti-C9orf72 antibodies named sc-138763 and HPA023873 showed that C9orf72 is expressed chiefly in the cytoplasm of neurons, and is concentrated in the synaptic terminals in the brains of FTD/ALS with or without C9orf72 repeat expansion as well as those of controls. At present, a pathological role of C9orf72 in the process of neurodegeneration remains unknown.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Spain 1 2%
United Kingdom 1 2%
Unknown 61 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 18%
Researcher 9 14%
Student > Doctoral Student 8 12%
Student > Master 6 9%
Other 5 8%
Other 12 18%
Unknown 13 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 34%
Neuroscience 11 17%
Medicine and Dentistry 7 11%
Biochemistry, Genetics and Molecular Biology 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 5 8%
Unknown 13 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2024.
All research outputs
#8,262,445
of 25,374,647 outputs
Outputs from Alzheimer's Research & Therapy
#1,264
of 1,465 outputs
Outputs of similar age
#57,375
of 174,035 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#9
of 15 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,465 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,035 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.