| Title |
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
|
|---|---|
| Published in |
Nature Genetics, June 2016
|
| DOI | 10.1038/ng.3598 |
| Pubmed ID | |
| Authors |
Padhraig Gormley, Verneri Anttila, Bendik S Winsvold, Priit Palta, Tonu Esko, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Terho Lehtimäki, Antti-Pekka Sarin, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Paul M Ridker, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Jouke-Jan Hottenga, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Reedik Mägi, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Veikko Salomaa, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Lynn Cherkas, Linda M Pedersen, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Lili Milani, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Andres Metspalu, Christian Kubisch, David P Strachan, Michel D Ferrari, Andrea C Belin, Martin Dichgans, Maija Wessman, Arn M J M van den Maagdenberg, John-Anker Zwart, Dorret I Boomsma, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie |
| Abstract |
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10(-8)) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies. |
X Demographics
The data shown below were collected from the profiles of 220 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 63 | 29% |
| United Kingdom | 23 | 10% |
| Spain | 17 | 8% |
| Netherlands | 6 | 3% |
| Germany | 5 | 2% |
| Australia | 5 | 2% |
| Denmark | 4 | 2% |
| France | 3 | 1% |
| Norway | 3 | 1% |
| Other | 24 | 11% |
| Unknown | 67 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 127 | 58% |
| Scientists | 69 | 31% |
| Practitioners (doctors, other healthcare professionals) | 17 | 8% |
| Science communicators (journalists, bloggers, editors) | 7 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 559 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Germany | 2 | <1% |
| Finland | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 552 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 88 | 16% |
| Student > Ph. D. Student | 82 | 15% |
| Student > Bachelor | 65 | 12% |
| Student > Master | 50 | 9% |
| Other | 35 | 6% |
| Other | 99 | 18% |
| Unknown | 140 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 116 | 21% |
| Biochemistry, Genetics and Molecular Biology | 77 | 14% |
| Agricultural and Biological Sciences | 74 | 13% |
| Neuroscience | 44 | 8% |
| Computer Science | 13 | 2% |
| Other | 69 | 12% |
| Unknown | 166 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1118. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2022.
All research outputs
#13,652
of 25,766,791 outputs
Outputs from Nature Genetics
#20
of 7,619 outputs
Outputs of similar age
#197
of 371,197 outputs
Outputs of similar age from Nature Genetics
#2
of 68 outputs
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