"In this prospective meta-analysis of clinical trials of critically ill patients with COVID-19, administration of systemic corticosteroids, compared with usual care or placebo, was associated with lower 28-day all-cause mortality." https://t.co/ZBDUBeBRSt
PMAs can use individual participant data or conventional meta-analysis of aggregated data - here's examples (own involvement): https://t.co/XhPMg6RR8I https://t.co/kpc09apqyu More next week - for an introduction to these threads, see https://t.co/pnknGTOG
@truthplease36 @EnglishLehrer @chrismartenson Then why didn't they ban dexamethasone? It's off-patent too, it's just that the data is actually really clear that it works. https://t.co/nmr4uUKYWF
@Sporph @chrismartenson If that's true, why didn't dexamethasone, shown to actually work mid 2020, stop the vaccines from getting EUA? https://t.co/nmr4uUKYWF Spoiler: It's because that isn't how the EUA process works: https://t.co/Y24Au2UGOw
@BoussageonR ça sort en revue systématique https://t.co/Z6nAznuqFi, mais tu vas dire qu'il faudrait une 2eme étude "positive" pour confirmer le signal ;)
RT @FaheemYounus: Excellent News! An analysis of 7 randomized trials with 1703 CRITICAL COVID patients on steroids in 12 countries Showed…
@AltMiddlePeds @EWoodhouse7 Yeah, RECOVERY came out in 6/2020 as I recall & various others as well, seems like ages ago now... https://t.co/PrTp5biycT
Let's look at the gold standard, or 'benchmark' (in their words) meta-analysis of RCTs by WHO (https://t.co/LLBycZIsS3). Shockingly, it seems the effects estimated from RCTs vary even more (OR from 0.46-4)! https://t.co/wkZvkQuvRq
@gsmartinmd Am not surprised by this finding . RECOVERY data startlingly good in ventilated patients (https://t.co/x6JdhqoOsU) but modestly good in hospitalized patients (https://t.co/ceb6ybLzJY). Something’s gotta give
@pirate_teddy @horschack @DoctorAnarchist Sometimes you need to wave the bullsh!t Flag...and inhaled corticosteroids are still somehow controversial to the point that NIH neither recommends for or against. They did crappy studies to dissuade people. Yes, t
@cornbugs @JanetG988 @highland_mn @drscottjensen https://t.co/9elXQxGYHX The usual care mentioned in this study was mechanical ventilation. Now admit you are a goosestepper who is programmed and move on
RT @iamyourgasman: Derek Angus on #COVID19 #ards and steroids #lives2022 people wanted to give steroids, there’s were good reasons not to.…
RT @WhistlingDixie4: But not for those without supplementary oxygen requirement (increased morality but did cross line) Then more trials i…
But not for those without supplementary oxygen requirement (increased morality but did cross line) Then more trials in critically ill CAPE Covid 🇫🇷 CoDex 🇧🇷 ReMAP-CAP 🌎 Meta-analysis published before end of in 2020 lead to who REACT guidelines… htt
Derek Angus on #COVID19 #ards and steroids #lives2022 people wanted to give steroids, there’s were good reasons not to. Magically, the new disease let us to do RCTs and report them at lightning pace. https://t.co/XqAtU3Wn7f https://t.co/4lkldxfvZG
@PampireRN @Immack3 @PennyWatrasDana @1therhino @StephenMosby @JamesMelville So a meta-analysis of 7 RCTs demonstrating that dex reduced mortality by 20% is wrong - its useless. Are you really clinical? Because evidence based medicine is fundamental for im
@TroyDellOrfano @NastyProud @RepGosar Troy D. claims to be "a scientist" yet still is unable and/or unwilling to provide any actual supporting evidence . . . Here again (as above) are the six tweets full of sourced evidentiary data https://t.co/QXoQ5c6j
We are not the first ones to suggest early steroids are not harmful for COVID patients. COVID specific viral kinetic studies and a meta-analysis support this too: https://t.co/Lq710mnKwa https://t.co/rRGedjwdxz
RT @nickmmark: After RECOVERY the question became not “should my hypoxic patient with COVID be on steroids?” but “which steroid?” & “what d…
RT @nickmmark: After RECOVERY the question became not “should my hypoxic patient with COVID be on steroids?” but “which steroid?” & “what d…
RT @nickmmark: After RECOVERY the question became not “should my hypoxic patient with COVID be on steroids?” but “which steroid?” & “what d…
RT @nickmmark: After RECOVERY the question became not “should my hypoxic patient with COVID be on steroids?” but “which steroid?” & “what d…
After RECOVERY the question became not “should my hypoxic patient with COVID be on steroids?” but “which steroid?” & “what dose?” The first meta-analysis after RECOVERY looked at 1700 patients in 7 studies but didn’t find an obvious answer. https://t
RT @AndersPerner: 2/x A blinded trial on hydrocortisone vs placebo for pts with COVID-19 and severe hypoxia showing included in the @WHO me…
RT @AndersPerner: 2/x A blinded trial on hydrocortisone vs placebo for pts with COVID-19 and severe hypoxia showing included in the @WHO me…
RT @AndersPerner: 2/x A blinded trial on hydrocortisone vs placebo for pts with COVID-19 and severe hypoxia showing included in the @WHO me…
RT @azizmertipekci: Buraya da steroid kullanımının Covid’e bağlı ölümleri azalttığına dair çalışmayı koyuyorum. Yoğurt/turşu ve Covid mor…
Buraya da steroid kullanımının Covid’e bağlı ölümleri azalttığına dair çalışmayı koyuyorum. Yoğurt/turşu ve Covid mortalitesi üzerine çalışmalarınız varsa lütfen paylaşın @Ferhatarslandr seve seve okurum 🙂 https://t.co/Su9NZECd2q
@AmbrizMau Quizá podría parecer muy grande la diferencia que esperaban encontrar los autores, pero tal vez esté basado en la eficiencia observada con el uso de esteroides, que va del 18 - 50%. Ref: https://t.co/WjvjW5nOi0
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COV… https://t.co/8F0UNMiLbJ
Next thing you find is a meta-analysis (https://t.co/0CtyXsljqi) looking at 7 RCTs of dexamethasone, including the RECOVERY one discussed above. Endpoint for all studies: death. Statistics measuring inconsistency among the studies find little inconsistenc
@AlexandreBorto8 @Ree_Lucci @Sergio64029292 @Osvaldogdavila @charlie_mouch @realmice @lhmandetta @KimKataguiri É diferente quando se usa em pacientes já em estado grave. Aí, se vê resultados: https://t.co/6fQ30zBhnG
RT @BradMD: 2020 Review: Association Between Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 https://t.c…
2020 Review: Association Between Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 https://t.co/XMXntZNLOR via @JAMA_current part of @JAMANetwork
RT @MRCCTU: See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝http…
RT @SCCMPresident: #TBT to one year ago today the REACT study in @JAMA_current showing benefits of steroids for treating severe #COVID19…
#TBT to one year ago today the REACT study in @JAMA_current showing benefits of steroids for treating severe #COVID19 https://t.co/4zdboaoXyn
RT @carpe_diem0820: COVID-19患者1703例を含む7RCTの前向きmetaAで647人が死亡 コルチコステロイド投与群では、通常のケアやプラセボ群と比較して28日全死因死亡率が低い(OR 0.66) Association Between Syste…
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 https://t.co/ZcxxxfmKmn
@kosik_md @DawidDziwoki Ad.1. dr Bodnar z powodzeniem leczył amantadyną i to jest fakt, Ad.2. iwermektyna działa, badania: https://t.co/dhPas5kkkx Ad.3. leki sterydowe zmniejszają ryzyko zgonu z powodu covid https://t.co/6i9XKtsUBM
RT @academiaer1: Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19:…
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis | Critical Care Medicine | JAMA | JAMA Network https://t.co/v2gdSxlD8p @academiaer1 @relucho #ACADEMIAEMERGENCIAS http
RT @Dotix8: @mrs_lydia6 Były nawet prowadzone badania, w których potwierdzono skuteczność leków sterydowych w leczeniu ciężkiego przebiegu…
RT @Dotix8: @mrs_lydia6 Były nawet prowadzone badania, w których potwierdzono skuteczność leków sterydowych w leczeniu ciężkiego przebiegu…
RT @Dotix8: @mrs_lydia6 Były nawet prowadzone badania, w których potwierdzono skuteczność leków sterydowych w leczeniu ciężkiego przebiegu…
RT @Dotix8: @mrs_lydia6 Były nawet prowadzone badania, w których potwierdzono skuteczność leków sterydowych w leczeniu ciężkiego przebiegu…
@mrs_lydia6 Były nawet prowadzone badania, w których potwierdzono skuteczność leków sterydowych w leczeniu ciężkiego przebiegu covid /zmniejszały ryzyko zgonu/ https://t.co/6i9XKtsUBM
@__OSN__ @Dctrrz @11z1 @newmlx @shfyy1234 @AsieriKhalied @kwtil https://t.co/NUnOksxLg6 دراسة جمعت بين اكثر من تجربة عن استخدام الكورزتيزون والادوية العادية فمرضى الكورونا والنتيجة كانت ان نسبة الوفاة للي استخدموا الكورتيزون اقل
RT @shreya__kataria: 🔅The findings from this meta-analysis provide evidence that treatment with corticosteroids is associated with reduced…
Los corticoides son el único tratamiento que reduce mortalidad de COVID. Deben de ser utilizados en pacientes internados con necesidad de oxígeno. https://t.co/Ca0CSGhfmJ
RT @MRCCTU: See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝http…
RT @MRCCTU: See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝http…
RT @MRCCTU: See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝http…
RT @MRCCTU: See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝http…
See how prospective #metaanalysis has provided timely, reliable and thorough evaluations of therapies for prostate cancer 📝https://t.co/iCrJqo5biE 📝https://t.co/fnMLUHMMRF 📝https://t.co/E2EajBHyFV 📝https://t.co/L4eaWIxuND and COVID-19 📝https://t.co/LkYvyk
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
RT @shams_z: Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covi…
Systemic steroid use is associated with lower 28-day all-cause mortality. If given choice of coming out alive from severe covid and dealing with some side effects after recovery, I am sure what I will pick. Aap kya chunenge? https://t.co/AnrAgaRQHM
RT @shreya__kataria: 🔅The findings from this meta-analysis provide evidence that treatment with corticosteroids is associated with reduced…
RT @shreya__kataria: 🔅The findings from this meta-analysis provide evidence that treatment with corticosteroids is associated with reduced…
🔅The findings from this meta-analysis provide evidence that treatment with corticosteroids is associated with reduced mortality for critically ill pts with COVID-19. https://t.co/0c9uD416m9 🔗 https://t.co/HRhFqBhXLT 🔗 https://t.co/EgJC8gwzEU
@AbdTahrani On confirmatory: https://t.co/AHTm02rv55
@baratti_boffa dopodiche ci sono gli RCT https://t.co/NtyE34ytZq
@123Jsun123 @JacobGudiol Vad gäller vitamin D osv framgår det ju här att de inte är demonstrerade effekter. De enda de listar som signifikanta är för remdesivir, tocilizumab & sarilumab. Dock har ju kortikosteroider bevisad effekt, se tex meta-analys
RT @Abraham_RMI: 3. Ahora, de acuerdo a este meta-analisis (https://t.co/WjvjW5nOi0 ), el uso de esteroides sistémicos disminuye el riesgo…
3. Ahora, de acuerdo a este meta-analisis (https://t.co/WjvjW5nOi0 ), el uso de esteroides sistémicos disminuye el riesgo de un descenlace fatal por #COVID19 en un 34%, con un intervalo que va del 18 al 47% 😃 https://t.co/In2zZuarNT
RT @gabe_fontaine: Meta-analysis of #steroids (#dexamethasone, #methylprednisolone, #hydrocortisone) in patients with COVID-19. Associati…
@deltapi84 @drsimonegold In contrast, dexamethasone, a cheap off-patent drug has been shown to reduce mortality of #COVID19 patients. https://t.co/8zJ4IaN8UP
This forest plot from the @JAMA_current SR&MA https://t.co/2WJv6uklj3 looking at mortality and steroids in critically ill COVID suggests a class effect with steroids. However, looking closer, you can see that >75% of the study data comes from dex an
@Fefeexcacau @affonsopj @BolsonaroSP a minha conta kkkk cm mais de 3k de seguidores e interajo todo dia e sua cm menos de 400 seguidores kkkkkk vai mentir assim lá na china, ah segue estudo https://t.co/xFBKTt8IhJ
@msh_manu @f_g_zampieri @diazjv Outstanding, this will inform practice directly as did the one on steroid use https://t.co/7vXL4W2JEi via @JAMA_current part of @JAMANetwork
@fuegomudo @dangarcar Bueno.. Venga. Te pongo el link de los 284 artículos publicados hasta la fecha q relacionan dexametasona y covid. https://t.co/uo1oxuSmxN Y añado el meta análisis q demuestra menor mortalidad de los pac graves q reciben corticoides h
RT @iceman_ex: In terms of therapies: What works- Steroids https://t.co/uTcPkVWVYL What doesn’t work: HCQ, Remdesivir, Interferon B-1 alp…
RT @iceman_ex: In terms of therapies: What works- Steroids https://t.co/uTcPkVWVYL What doesn’t work: HCQ, Remdesivir, Interferon B-1 alp…
In terms of therapies: What works- Steroids https://t.co/uTcPkVWVYL What doesn’t work: HCQ, Remdesivir, Interferon B-1 alpha https://t.co/2baOJR1wg7 what we don’t know about : Anti IL-6 (Tocilizumab)- conflicting data (new data from REMAP-CAP due today!
@SteveJoffe Notably, though, there's been WAY more attention to the 5 person case series than the much more meaningful (& robust) meta-analysis of the role of steroids in COVID https://t.co/Zuy6f6VSX9 https://t.co/jDDpsEikZk
Metaanalisis REACT.1703 pacientes [1025 atención habitual o placebo vs 678 con corticosteroides]. OR fue 0,66 [IC95% 0,53-0,82; P<0,001] de mortalidad con reducción absoluta de mortalidad de 8% [32% esteroides vs 40% de atención habitual o placebo]/2 ht
Metaanlisis de grupoREACT. Esteroides en pacientes con #COVID19 criticamente enfermos/1 @SOVETORAX https://t.co/m34QcMDeOx
RT @Abraham_RMI: @OrlandoRPN Si si, este está “mejorcito”, pero mezcla estudios observacionales con ECAs. Esta revisión sistemática publica…
RT @Abraham_RMI: @OrlandoRPN Si si, este está “mejorcito”, pero mezcla estudios observacionales con ECAs. Esta revisión sistemática publica…