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Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection

Overview of attention for article published in Immunity, June 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 3,812)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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83 Dimensions

Readers on

mendeley
246 Mendeley
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3 CiteULike
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Title
Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection
Published in
Immunity, June 2016
DOI 10.1016/j.immuni.2016.06.002
Pubmed ID
Authors

Marieke Pingen, Steven R. Bryden, Emilie Pondeville, Esther Schnettler, Alain Kohl, Andres Merits, John K. Fazakerley, Gerard J. Graham, Clive S. McKimmie

Abstract

Aedes aegypti mosquitoes are responsible for transmitting many medically important viruses such as those that cause Zika and dengue. The inoculation of viruses into mosquito bite sites is an important and common stage of all mosquito-borne virus infections. We show, using Semliki Forest virus and Bunyamwera virus, that these viruses use this inflammatory niche to aid their replication and dissemination in vivo. Mosquito bites were characterized by an edema that retained virus at the inoculation site and an inflammatory influx of neutrophils that coordinated a localized innate immune program that inadvertently facilitated virus infection by encouraging the entry and infection of virus-permissive myeloid cells. Neutrophil depletion and therapeutic blockade of inflammasome activity suppressed inflammation and abrogated the ability of the bite to promote infection. This study identifies facets of mosquito bite inflammation that are important determinants of the subsequent systemic course and clinical outcome of virus infection.

Twitter Demographics

The data shown below were collected from the profiles of 57 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 3 1%
Brazil 2 <1%
Korea, Republic of 1 <1%
Japan 1 <1%
Indonesia 1 <1%
Unknown 234 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 56 23%
Student > Ph. D. Student 50 20%
Student > Master 32 13%
Student > Bachelor 27 11%
Other 15 6%
Other 39 16%
Unknown 27 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 73 30%
Immunology and Microbiology 48 20%
Biochemistry, Genetics and Molecular Biology 35 14%
Medicine and Dentistry 23 9%
Veterinary Science and Veterinary Medicine 7 3%
Other 23 9%
Unknown 37 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 989. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2017.
All research outputs
#5,582
of 15,120,749 outputs
Outputs from Immunity
#5
of 3,812 outputs
Outputs of similar age
#185
of 264,695 outputs
Outputs of similar age from Immunity
#1
of 67 outputs
Altmetric has tracked 15,120,749 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,695 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.