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Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

Overview of attention for article published in Journal of Neuroinflammation, August 2012
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Title
Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway
Published in
Journal of Neuroinflammation, August 2012
DOI 10.1186/1742-2094-9-204
Pubmed ID
Authors

Ana Patrícia Simões, João A Duarte, Fabienne Agasse, Paula Margarida Canas, Angelo R Tomé, Paula Agostinho, Rodrigo A Cunha

Abstract

Blockade of adenosine A(2A) receptors (A(2A)R) affords robust neuroprotection in a number of brain conditions, although the mechanisms are still unknown. A likely candidate mechanism for this neuroprotection is the control of neuroinflammation, which contributes to the amplification of neurodegeneration, mainly through the abnormal release of pro-inflammatory cytokines such as interleukin(IL)-1β. We investigated whether A(2A)R controls the signaling of IL-1β and its deleterious effects in cultured hippocampal neurons.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Austria 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Ph. D. Student 9 21%
Professor > Associate Professor 4 9%
Professor 3 7%
Student > Bachelor 3 7%
Other 10 23%
Unknown 4 9%
Readers by discipline Count As %
Neuroscience 12 28%
Agricultural and Biological Sciences 10 23%
Biochemistry, Genetics and Molecular Biology 5 12%
Psychology 2 5%
Philosophy 1 2%
Other 5 12%
Unknown 8 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2012.
All research outputs
#15,249,959
of 22,675,759 outputs
Outputs from Journal of Neuroinflammation
#1,730
of 2,605 outputs
Outputs of similar age
#107,503
of 169,121 outputs
Outputs of similar age from Journal of Neuroinflammation
#24
of 48 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,605 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,121 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.