Title |
Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovisin the aortic tissue of patients with Takayasu’s arteritis
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Published in |
BMC Infectious Diseases, August 2012
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DOI | 10.1186/1471-2334-12-194 |
Pubmed ID | |
Authors |
María Elena Soto, Ma Del Carmen Ávila-Casado, Claudia Huesca-Gómez, Gilberto Vargas Alarcon, Vicente Castrejon, Virgilia Soto, Sergio Hernandez, Nilda Espinola-Zavaleta, Maite Vallejo, Pedro A Reyes, Ricardo Gamboa |
Abstract |
Takayasu's arteritis (TA) is a chronic inflammatory disease affecting the large arteries and their branches; its etiology is still unknown. In individuals suffering from TA, arterial inflammation progresses to stenosis and/or occlusion, leading to organ damage and affecting survival. Relation of TA with Mycobacterium tuberculosis has been known, but there have been only a few systematic studies focusing on this association. The IS6110 sequence identifies the Mycobacterium tuberculosis complex and the HupB establishes the differences between M. tuberculosis and M. bovis. Our objective was to search the presence of IS6110 and HupB genes in aorta of patients with TA. |
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Geographical breakdown
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Unknown | 3 | 100% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Turkey | 1 | 2% |
Ireland | 1 | 2% |
Unknown | 55 | 95% |
Demographic breakdown
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Researcher | 10 | 17% |
Student > Master | 7 | 12% |
Student > Bachelor | 6 | 10% |
Student > Ph. D. Student | 5 | 9% |
Professor > Associate Professor | 4 | 7% |
Other | 8 | 14% |
Unknown | 18 | 31% |
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Nursing and Health Professions | 2 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 6 | 10% |
Unknown | 19 | 33% |