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Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae

Overview of attention for article published in BMC Microbiology, July 2012
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Title
Comparative analysis of diguanylate cyclase and phosphodiesterase genes in Klebsiella pneumoniae
Published in
BMC Microbiology, July 2012
DOI 10.1186/1471-2180-12-139
Pubmed ID
Authors

Diana P Cruz, Mónica G Huertas, Marcela Lozano, Lina Zárate, María Mercedes Zambrano

Abstract

Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections. One of the factors that contribute to virulence is its capacity to form biofilms on diverse biotic and abiotic surfaces. The second messenger Bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is a ubiquitous signal in bacteria that controls biofilm formation as well as several other cellular processes. The cellular levels of this messenger are controlled by c-di-GMP synthesis and degradation catalyzed by diguanylate cyclase (DGC) and phophodiesterase (PDE) enzymes, respectively. Many bacteria contain multiple copies of these proteins with diverse organizational structure that highlight the complex regulatory mechanisms of this signaling network. This work was undertaken to identify DGCs and PDEs and analyze the domain structure of these proteins in K. pneumoniae.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 18%
Professor > Associate Professor 5 13%
Student > Master 5 13%
Researcher 4 11%
Student > Doctoral Student 3 8%
Other 7 18%
Unknown 7 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 39%
Biochemistry, Genetics and Molecular Biology 4 11%
Medicine and Dentistry 4 11%
Immunology and Microbiology 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 8%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2012.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from BMC Microbiology
#2,667
of 3,163 outputs
Outputs of similar age
#148,270
of 164,617 outputs
Outputs of similar age from BMC Microbiology
#30
of 34 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,163 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.