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Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat

Overview of attention for article published in Acta Cirurgica Brasileira, February 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 133)
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
23 Mendeley
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Title
Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
Published in
Acta Cirurgica Brasileira, February 2016
DOI 10.1590/s0102-865020160020000008
Pubmed ID
Authors

Siamak Reyhani-Rad, Javad Mahmoudi

Abstract

To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using beam traversal test 10, 30 and 60 minutes after intraperitoneal injections of the drugs (caffeine, SCH58261). The results showed that 6-OHDA (8 μg/rat, Intra-SNc) induced motor disorders of Parkinson's disease and increased elapsed time in the beam test (p<0.001). Injection of caffeine (30 mg/kg, i.p.) and SCH58261 (2 mg/kg, i.p.) attenuated elapsed time on beam (p<0.01 and p<0.001). We showed that acute administration of caffeine and SCH 58261 can improve the 6-OHDA-induced bradykinesia and motor disturbance. Adenosine A2AR antagonists improve 6-OHDA-motor deficit and this effect seems to be mediated by the inhibition of A2A presynaptic receptors in substantia nigra pars compacta.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 17%
Student > Master 4 17%
Researcher 3 13%
Student > Ph. D. Student 2 9%
Student > Postgraduate 2 9%
Other 1 4%
Unknown 7 30%
Readers by discipline Count As %
Neuroscience 5 22%
Medicine and Dentistry 4 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Agricultural and Biological Sciences 2 9%
Psychology 1 4%
Other 0 0%
Unknown 9 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2016.
All research outputs
#2,185,975
of 13,474,817 outputs
Outputs from Acta Cirurgica Brasileira
#2
of 133 outputs
Outputs of similar age
#54,616
of 264,407 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#1
of 2 outputs
Altmetric has tracked 13,474,817 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 133 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them