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Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen

Overview of attention for article published in PLoS ONE, June 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
15 tweeters
facebook
2 Facebook pages
reddit
1 Redditor

Readers on

mendeley
8 Mendeley
citeulike
1 CiteULike
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Title
Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen
Published in
PLoS ONE, June 2016
DOI 10.1371/journal.pone.0158019
Pubmed ID
Authors

Javid, Ashkan, Zlotnikov, Nataliya, Pětrošová, Helena, Tang, Tian Tian, Zhang, Yang, Bansal, Anil K, Ebady, Rhodaba, Parikh, Maitry, Ahmed, Mijhgan, Sun, Chunxiang, Newbigging, Susan, Kim, Yae Ram, Santana Sosa, Marianna, Glogauer, Michael, Moriarty, Tara J, Ashkan Javid, Nataliya Zlotnikov, Helena Pětrošová, Tian Tian Tang, Yang Zhang, Anil K. Bansal, Rhodaba Ebady, Maitry Parikh, Mijhgan Ahmed, Chunxiang Sun, Susan Newbigging, Yae Ram Kim, Marianna Santana Sosa, Michael Glogauer, Tara J. Moriarty, Brian Stevenson

Abstract

Insulin-insufficient type 1 diabetes is associated with attenuated bactericidal function of neutrophils, which are key mediators of innate immune responses to microbes as well as pathological inflammatory processes. Neutrophils are central to immune responses to the Lyme pathogen Borrelia burgdorferi. The effect of hyperglycemia on host susceptibility to and outcomes of B. burgdorferi infection has not been examined. The present study investigated the impact of sustained obesity-independent hyperglycemia in mice on bacterial clearance, inflammatory pathology and neutrophil responses to B. burgdorferi. Hyperglycemia was associated with reduced arthritis incidence but more widespread tissue colonization and reduced clearance of bacterial DNA in multiple tissues including brain, heart, liver, lung and knee joint. B. burgdorferi uptake and killing were impaired in neutrophils isolated from hyperglycemic mice. Thus, attenuated neutrophil function in insulin-insufficient hyperglycemia was associated with reduced B. burgdorferi clearance in target organs. These data suggest that investigating the effects of comorbid conditions such as diabetes on outcomes of B. burgdorferi infections in humans may be warranted.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 13%
Sweden 1 13%
Canada 1 13%
Unknown 5 63%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 50%
Professor 1 13%
Student > Bachelor 1 13%
Student > Doctoral Student 1 13%
Professor > Associate Professor 1 13%
Other 0 0%
Readers by discipline Count As %
Medicine and Dentistry 4 50%
Immunology and Microbiology 2 25%
Agricultural and Biological Sciences 1 13%
Economics, Econometrics and Finance 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#899,247
of 7,705,958 outputs
Outputs from PLoS ONE
#19,011
of 109,477 outputs
Outputs of similar age
#43,582
of 260,088 outputs
Outputs of similar age from PLoS ONE
#865
of 4,552 outputs
Altmetric has tracked 7,705,958 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 109,477 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 4,552 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.