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SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels

Overview of attention for article published in PLoS ONE, September 2020
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 158,329)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
61 news outlets
blogs
2 blogs
twitter
1365 tweeters
facebook
11 Facebook pages
reddit
8 Redditors

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
52 Mendeley
Title
SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels
Published in
PLoS ONE, September 2020
DOI 10.1371/journal.pone.0239252
Pubmed ID
Authors

Harvey W. Kaufman, Justin K. Niles, Martin H. Kroll, Caixia Bi, Michael F. Holick

Abstract

Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates. Over 190,000 patients from all 50 states with SARS-CoV-2 results performed mid-March through mid-June, 2020 and matching 25(OH)D results from the preceding 12 months were included. Residential zip code data was required to match with US Census data and perform analyses of race/ethnicity proportions and latitude. A total of 191,779 patients were included (median age, 54 years [interquartile range 40.4-64.7]; 68% female. The SARS-CoV-2 positivity rate was 9.3% (95% C.I. 9.2-9.5%) and the mean seasonally adjusted 25(OH)D was 31.7 (SD 11.7). The SARS-CoV-2 positivity rate was higher in the 39,190 patients with "deficient" 25(OH)D values (<20 ng/mL) (12.5%, 95% C.I. 12.2-12.8%) than in the 27,870 patients with "adequate" values (30-34 ng/mL) (8.1%, 95% C.I. 7.8-8.4%) and the 12,321 patients with values ≥55 ng/mL (5.9%, 95% C.I. 5.5-6.4%). The association between 25(OH)D levels and SARS-CoV-2 positivity was best fitted by the weighted second-order polynomial regression, which indicated strong correlation in the total population (R2 = 0.96) and in analyses stratified by all studied demographic factors. The association between lower SARS-CoV-2 positivity rates and higher circulating 25(OH)D levels remained significant in a multivariable logistic model adjusting for all included demographic factors (adjusted odds ratio 0.984 per ng/mL increment, 95% C.I. 0.983-0.986; p<0.001). SARS-CoV-2 positivity is strongly and inversely associated with circulating 25(OH)D levels, a relationship that persists across latitudes, races/ethnicities, both sexes, and age ranges. Our findings provide impetus to explore the role of vitamin D supplementation in reducing the risk for SARS-CoV-2 infection and COVID-19 disease.

Twitter Demographics

The data shown below were collected from the profiles of 1,365 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Other 8 15%
Student > Master 6 12%
Unspecified 5 10%
Student > Doctoral Student 4 8%
Other 15 29%
Unknown 4 8%
Readers by discipline Count As %
Medicine and Dentistry 17 33%
Nursing and Health Professions 6 12%
Agricultural and Biological Sciences 4 8%
Unspecified 4 8%
Social Sciences 3 6%
Other 10 19%
Unknown 8 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1509. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2020.
All research outputs
#3,023
of 16,085,131 outputs
Outputs from PLoS ONE
#40
of 158,329 outputs
Outputs of similar age
#278
of 257,825 outputs
Outputs of similar age from PLoS ONE
#1
of 248 outputs
Altmetric has tracked 16,085,131 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 158,329 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,825 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 248 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.