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Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

Overview of attention for article published in Malaria Journal, August 2012
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Title
Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
Published in
Malaria Journal, August 2012
DOI 10.1186/1475-2875-11-293
Pubmed ID
Authors

Joel Tarning, Frank Kloprogge, Patrice Piola, Mehul Dhorda, Sulaiman Muwanga, Eleanor Turyakira, Nitra Nuengchamnong, François Nosten, Nicholas PJ Day, Nicholas J White, Philippe J Guerin, Niklas Lindegardh

Abstract

Malaria in pregnancy increases the risk of maternal anemia, abortion and low birth weight. Approximately 85.3 million pregnancies occur annually in areas with Plasmodium falciparum transmission. Pregnancy has been reported to alter the pharmacokinetic properties of many anti-malarial drugs. Reduced drug exposure increases the risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Burkina Faso 1 1%
United States 1 1%
Thailand 1 1%
Unknown 87 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 18%
Student > Ph. D. Student 15 16%
Student > Master 10 11%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 20 22%
Unknown 17 18%
Readers by discipline Count As %
Medicine and Dentistry 39 42%
Agricultural and Biological Sciences 12 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Biochemistry, Genetics and Molecular Biology 3 3%
Social Sciences 3 3%
Other 9 10%
Unknown 21 23%