Title |
Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
|
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Published in |
Malaria Journal, August 2012
|
DOI | 10.1186/1475-2875-11-293 |
Pubmed ID | |
Authors |
Joel Tarning, Frank Kloprogge, Patrice Piola, Mehul Dhorda, Sulaiman Muwanga, Eleanor Turyakira, Nitra Nuengchamnong, François Nosten, Nicholas PJ Day, Nicholas J White, Philippe J Guerin, Niklas Lindegardh |
Abstract |
Malaria in pregnancy increases the risk of maternal anemia, abortion and low birth weight. Approximately 85.3 million pregnancies occur annually in areas with Plasmodium falciparum transmission. Pregnancy has been reported to alter the pharmacokinetic properties of many anti-malarial drugs. Reduced drug exposure increases the risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Burkina Faso | 1 | 1% |
United States | 1 | 1% |
Thailand | 1 | 1% |
Unknown | 87 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 18% |
Student > Ph. D. Student | 15 | 16% |
Student > Master | 10 | 11% |
Student > Bachelor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Other | 20 | 22% |
Unknown | 17 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 42% |
Agricultural and Biological Sciences | 12 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Social Sciences | 3 | 3% |
Other | 9 | 10% |
Unknown | 21 | 23% |