@TheCarnivoreKid @Veganella_ AFAIK those 2 SNPs are thought to lower risk by lowering LDL-c/apoB (probably LDLR gain of function), not by protecting against high apoB (if lever is pushed enough to still raise it) (also net effect of all genes is the key)
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@FatEmperor @drbrophy overall findings (lower LDL and lower risk of CVD) replicated in other mendelian randomization studies: https://t.co/csmX2gy3PL https://t.co/RxtS0Ravlj I've never heard a cogent argument against these mendelian rando findings but i
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@ajwodecki I'm not selling drugs. LIFE LONG low cholesterol however is clearly protective https://t.co/bYNYcOWuYO https://t.co/2BtxONHU6z
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