↓ Skip to main content

Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

Overview of attention for article published in BMC Genomics, June 2016
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 X users

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
45 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
Published in
BMC Genomics, June 2016
DOI 10.1186/s12864-016-2787-y
Pubmed ID
Authors

Lyndsay A. Staley, Mark T. W. Ebbert, Daniel Bunker, Matthew Bailey, for the Alzheimer’s Disease Neuroimaging Initiative, Perry G. Ridge, Alison M. Goate, John S. K. Kauwe

Abstract

Prostatic Acid Phosphatase (PAP) is an enzyme that is produced primarily in the prostate and functions as a cell growth regulator and potential tumor suppressor. Understanding the genetic regulation of this enzyme is important because PAP plays an important role in prostate cancer and is expressed in other tissues such as the brain. We tested association between 5.8 M SNPs and PAP levels in cerebrospinal fluid across 543 individuals in two datasets using linear regression. We then performed meta-analyses using METAL =with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets, identifying 289 candidate SNPs that affect PAP cerebrospinal fluid levels. We analyzed each of these SNPs individually and prioritized SNPs that had biologically meaningful functional annotations in wANNOVAR (e.g. non-synonymous, stop gain, 3' UTR, etc.) or had a RegulomeDB score less than 3. Thirteen SNPs met our criteria, suggesting they are candidate causal alleles that underlie ACPP regulation and expression. Given PAP's expression in the brain and its role as a cell-growth regulator and tumor suppressor, our results have important implications in brain health such as cancer and other brain diseases including neurodegenerative diseases (e.g., Alzheimer's disease and Parkinson's disease) and mental health (e.g., anxiety, depression, and schizophrenia).

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 13%
Researcher 5 11%
Student > Bachelor 5 11%
Professor 3 7%
Other 3 7%
Other 11 24%
Unknown 12 27%
Readers by discipline Count As %
Neuroscience 9 20%
Medicine and Dentistry 6 13%
Psychology 6 13%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 2 4%
Other 4 9%
Unknown 15 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2016.
All research outputs
#14,267,420
of 22,880,230 outputs
Outputs from BMC Genomics
#5,708
of 10,666 outputs
Outputs of similar age
#201,642
of 352,012 outputs
Outputs of similar age from BMC Genomics
#120
of 226 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,666 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,012 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 226 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.