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The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica Communications, June 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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1 news outlet
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2 X users

Citations

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54 Dimensions

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100 Mendeley
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Title
The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease
Published in
Acta Neuropathologica Communications, June 2016
DOI 10.1186/s40478-016-0339-y
Pubmed ID
Authors

Luke W. Bonham, Rahul S. Desikan, Jennifer S. Yokoyama, for the Alzheimer’s Disease Neuroimaging Initiative

Abstract

Inflammation is becoming increasingly recognized as an important contributor to Alzheimer's disease (AD) pathogenesis. As a part of the innate immune system, the complement cascade enhances the body's ability to destroy and remove pathogens and has recently been shown to influence Alzheimer's associated amyloid and tau pathology. However, little is known in humans about the effects of the complement system and genetic modifiers of AD risk like the ε4 allele of apolioprotein E (APOE ε4) on AD pathobiology. We evaluated cerebrospinal fluid (CSF) protein levels from 267 individuals clinically diagnosed as cognitively normal, mild cognitive impairment, and AD. Using linear models, we assessed the relationship between APOE ε4 genotype, CSF Complement 3 (C3), CSF amyloid-β (amyloid) and CSF hyperphosphorylated tau (ptau). We found a significant interaction between APOE ε4 and CSF C3 on both CSF amyloid and CSF ptau. We also found that CSF C3 is only associated with CSF ptau after accounting for CSF amyloid. Our results support a conceptual model of the AD pathogenic cascade where a synergistic relationship between the complement cascade (C3) and APOE ε4 results in elevated Alzheimer's neurodegeneration and in turn, amyloid further regulates the effect of the complement cascade on downstream tau pathology.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 100 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 13%
Student > Master 13 13%
Other 10 10%
Student > Bachelor 10 10%
Researcher 10 10%
Other 18 18%
Unknown 26 26%
Readers by discipline Count As %
Neuroscience 20 20%
Agricultural and Biological Sciences 8 8%
Medicine and Dentistry 8 8%
Biochemistry, Genetics and Molecular Biology 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Other 18 18%
Unknown 32 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2018.
All research outputs
#3,077,881
of 22,880,230 outputs
Outputs from Acta Neuropathologica Communications
#638
of 1,379 outputs
Outputs of similar age
#57,560
of 352,012 outputs
Outputs of similar age from Acta Neuropathologica Communications
#13
of 33 outputs
Altmetric has tracked 22,880,230 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,379 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,012 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.